0000000000589419

AUTHOR

D. Spinelli

showing 19 related works from this author

Ciclodestrine borate. Sintesi, acidità e attività catalitica

1999

ciclodestrinesintesiSettore CHIM/06 - Chimica Organica
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Carotid plaque detection improves the predictve value of CHA2DS2-VASc score in patients with non-valvular atrial fibrilation: The ARAPACIS Study

2017

Abstract Background and aims Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA 2 DS 2 -VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA 2 DS 2 -VASc score. Methods We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography. Results VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Ad…

Atherosclerosis Atrial fibrillation Carotid plaque CHA2DS2-VASc score Stroke Vascular diseaseCarotid Artery DiseasesMaleAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA2DS2-VASc score; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk Assessment; Cardiology and Cardiovascular Medicine030204 cardiovascular system & hematologyatrialf fibrillation0302 clinical medicineRetrospective StudieRisk FactorsCarotid artery diseaseAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA; 2; DS; 2; -VASc score; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk AssessmentAtrial Fibrillation80 and over030212 general & internal medicineMyocardial infarctionStrokeDSAtherosclerosis; Atrial fibrillation; CHA(2)DS(2)-VASc score; Carotid plaque; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk AssessmentCHA 2 DS 2 -VASc scorePlaqueAtheroscleroticUltrasonographyAged 80 and overIncidenceDopplerAtrial fibrillationCarotid plaquePlaque AtheroscleroticStrokeSurvival RateItalyAtherosclerosiCHA(2)DS(2)-VASc scoreCardiologyartherosclerosis; atrial fibrillation; carotid plaque; CHA2DS2-VASc score; stroke; vascular disease; aged; aged 80 and over; ankle brachial index; atrialf fibrillation; carotid artery diseases; female; humans; incidence; italy; male; plaque atherosclerotic; retrospective studies; risk factors; survival rate; ultrasonography doppler; risk assessment; cardiology and cardiovascular medicineFemaleSettore SECS-S/01 - StatisticaCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyCHA2DS2-VASc score2Atherosclerosis; Atrial fibrillation; Carotid plaque; CHA 2 DS 2 -VASc score ; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk Assessment; Cardiology and Cardiovascular MedicineSocio-culturaleVascular diseaseRisk Assessment-VASc score03 medical and health sciencesInternal medicinemedicineHumansAnkle Brachial Indexcardiovascular diseasesRisk factorSurvival rateAgedRetrospective StudiesCarotid Artery DiseaseVascular diseasebusiness.industryRisk FactorUltrasonography Dopplermedicine.diseaseAtherosclerosisartherosclerosisCHA2DS2–VASc scoreCHAAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA; 2; DS; 2; -VASc score; Stroke; Vascular diseasebusiness
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The Boulton-Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-phenylhydrazones of 3-Benzo…

2014

The kinetics of the ring-into-ring conversion of some new (Z)-phenylhydrazones of 3-benzoyl-1,2,4-oxadiazole containing different nitrogen-substituents at C-5 (3b-d; X = NHMe, NMe2, and NHCOMe) into the relevant triazoles 4b-d have been examined in a wide range of pS+ (0.1-11.9) in 1:1 (v/v) dioxane/water solution. The obtained results have been compared with previous data concerning the (Z)-phenyl-hydrazone of 5-amino-3-benzoyl-1,2,4-oxadiazole (3a; X = NH2). All of the studied (Z)-phenylhydrazones rearrange through three different pathways (specific acid-catalysed, uncatalysed and general base-catalysed). The different effects of the substituents on the course of the rearrangement in the …

hydrazoneKinetics Rearrangement Heterocycles Hydrazones IsomerizationrearrangementkineticSettore CHIM/06 - Chimica OrganicaKinetics / Rearrangement / Heterocycles / Hydrazones / Isomerizationisomerizationheterocycle
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New examples of specific base catalysis in mononuclear rearrangements of heterocycles found via a designed modification of the side chain structure

2009

To select suitable candidates for the occurrence of specific-base-catalysis in MRH of (Z)-hydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole we have designed a modification of the side-chain structure by linking a strong electron-withdrawing system to the hydrazono group. Thus we have synthesized the (Z)-semicarbazone (3d), the (Z)-phenylsemicarbazone (3e), and the (Z)-acetylhydrazone (3f) of the above oxadiazole and examined their kinetic behavior in dioxane/water in a large range of proton concentrations (pS + 4.0 14.5). In all the pS+ range examined only a base-catalyzed process has been evidenced (no uncatalysed path occurs). The behavior at the largest pS+ values (the reactivity tends t…

Settore CHIM/06 - Chimica OrganicaMononuclear rearrangement of heterocycles base catalysis kinetic measurements
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Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

2018

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, pati…

MaleSettore MED/09 - Medicina Interna030204 cardiovascular system & hematologyPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsMajor cardiovascular eventCause of DeathRisk of mortalityPrevalenceMedicine030212 general & internal medicineProspective StudiesRegistriesProspective cohort studyStrokeCause of deathCOPDChronic obstructive pulmonary diseaseIncidenceHazard ratioAtrial fibrillation; Cardiovascular mortality; Chronic obstructive pulmonary disease; Major cardiovascular events; Aged; Atrial Fibrillation; Cardiovascular Diseases; Cause of Death; Endpoint Determination; Female; Follow-Up Studies; Humans; Incidence; Italy; Male; Predictive Value of Tests; Prevalence; Prospective Studies; Pulmonary Disease Chronic Obstructive; Registries; Risk Factors; Internal Medicine; Emergency MedicineAtrial fibrillationAtrial fibrillation Cardiovascular mortality Chronic obstructive pulmonary disease Major cardiovascular eventsItalyCardiovascular DiseasesCardiologyEmergency MedicineFemaleSettore SECS-S/01 - Statisticamedicine.medical_specialtyChronic ObstructiveCardiovascular mortalityEndpoint DeterminationAtrial fibrillation; Cardiovascular mortality; Chronic obstructive pulmonary disease; Major cardiovascular events; Aged; Atrial Fibrillation; Cardiovascular Diseases; Cause of Death; Endpoint Determination; Female; Follow-Up Studies; Humans; Incidence; Italy; Male; Predictive Value of Tests; Prevalence; Prospective Studies; Pulmonary Disease Chronic Obstructive; Registries; Risk FactorsSocio-culturalePulmonary Disease03 medical and health sciencesPredictive Value of TestsInternal medicineInternal MedicineHumanscardiovascular diseasesAtrial fibrillation; Cardiovascular mortality; Chronic obstructive pulmonary disease; Major cardiovascular eventsAgedbusiness.industryMajor cardiovascular eventsmedicine.diseaseAtrial fibrillationAtrial fibrillation; Cardiovascular mortality; Chronic obstructive pulmonary disease; Major cardiovascular events; Internal Medicine; Emergency MedicinebusinessMaceFollow-Up Studies
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On the structure of 3-acetylamino-5-methyl- 1,2,4-oxadiazole and on the fully degenerate rearrangements (FDR) of its anion: a stimulating comparison …

2009

An accurate crystal structure determination has provided evidence for a planar conformation for 3-acetylamino-5-methyl-1,2,4-oxadiazole (5), in agreement with quantum-mechanical calculations in the gas phase. In the crystal, a series of strong intermolecular N7H7...O9 hydrogen bonds link the amido groups of different molecules, causing the formation of infinite parallel ordered chains. The effect of the DMSO solvent on the energy and charge distribution of compound 5 and on its relevant 5S anion, involved in a fully degenerate rearrangement (FDR), has been deepened by quantum-mechanical DFT calculations. The calculated energy barrier for the FDR increases in going from in vacuo to DMSO, in …

Boulton–Katritzky reactionSettore CHIM/03 - Chimica Generale E InorganicarearrangementSettore CHIM/06 - Chimica Organicaazole-to-azole interconversiondensity functional calculationXray diffraction
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CCDC 868795: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-(2-Benzylidene-13-oxazolidin-3-yl)-22-dichlorobutan-1-oneExperimental 3D Coordinates
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CCDC 271045: Experimental Crystal Structure Determination

2005

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, G.Macaluso, N.Vivona, D.Spinelli, G.Giorgi|2005|J.Org.Chem.|70|3288|doi:10.1021/jo047766s

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-Trifluoromethyl-6-phenyl-2H-124-triazin-5-one Z-oxime p-bromobenzoateExperimental 3D Coordinates
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CCDC 630243: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-(Pentadecafluoroheptyl)-1-methyl-5-phenyl-1H-(124)-triazoleExperimental 3D Coordinates
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CCDC 868801: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-(2-Benzylidene-13-thiazinan-3-yl)-22-dichloro-2-phenylethanoneExperimental 3D Coordinates
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CCDC 868798: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-(3-Acetyl-2-benzylidenetetrahydropyrimidin-1(2H)-yl)-22-dichlorobutan-1-oneExperimental 3D Coordinates
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CCDC 630242: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN^1^-Methyl-5-hydroxylimino-3-pentadecafluoroheptyl-124-triazin-6-one ethanol solvateExperimental 3D Coordinates
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CCDC 868800: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal Structure1-(2-Benzylidene-13-thiazolidin-3-yl)-22-dichlorobutan-1-oneCell ParametersExperimental 3D Coordinates
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CCDC 868799: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal Structure1-(2-Benzylidene-13-thiazolidin-3-yl)-22-dichlorobutan-1-oneCell ParametersExperimental 3D Coordinates
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CCDC 868802: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

66'-Diethyl-77'-diphenyl-22'33'-tetrahydro-5H5'H-7a7a'-bipyrrolo[21-b][13]thiazole-55'-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 868796: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal Structure1-(3-Acetyl-2-ethylidenetetrahydropyrimidin-1(2H)-yl)-22-dichlorobutan-1-oneCell ParametersExperimental 3D Coordinates
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CCDC 868797: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters14-Acetyl-9-ethyl-15-oxa-1114-diazatetracyclo[7.5.1.0111.038]pentadeca-357-trien-10-oneExperimental 3D Coordinates
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CCDC 635325: Experimental Crystal Structure Determination

2010

Related Article: A.Mugnoli, G.Barone, S.Buscemi, C.Z.Lanza, A.Pace, M.Pani, D.Spinelli|2009|J.Phys.Org.Chem.|22|1086|doi:10.1002/poc.1563

Space GroupCrystallographyCrystal SystemN-(5-Methyl-124-oxadiazol-3-yl)acetamideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 630241: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureNO-Dibenzoyl-5-hydroxylamino-3-heptafluoropropyl-124-triazin-6-oneCell ParametersExperimental 3D Coordinates
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