0000000000591882

AUTHOR

Sudeshna Fisch

showing 2 related works from this author

Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling

2016

Background Ascending thoracic aortic aneurysm ( ATAA ) is driven by angiotensin II (Ang II ) and contributes to the development of left ventricular ( LV ) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments Ang II ‐induced abdominal aortic aneurysms in apolipoprotein E–deficient mice. We hypothesized that locally synthesized leptin mediates Ang II ‐induced ATAA . Methods and Results Following demonstration of leptin synthesis in samples of human ATAA associated with different etiologies, we modeled in situ leptin expression in apolipoprotein E–deficient mice by applying exogenous leptin on the surface of the ascending aorta. This treatm…

LeptinMale0301 basic medicineAortic valveTranslational StudiesMice Knockout ApoEaortic valve stenosisangiotensin II030204 cardiovascular system & hematologyLeft ventricular hypertrophyVascular MedicineMiceAortic aneurysm0302 clinical medicineVasoconstrictor AgentsMedicineCells CulturedOriginal ResearchAged 80 and overVentricular RemodelingLeptindigestive oral and skin physiologyMiddle Agedleft ventricular hypertrophymedicine.anatomical_structureAortic ValveAortic valve stenosiscardiovascular systemCardiologyFemaleHypertrophy Left VentricularCardiology and Cardiovascular Medicineaortic aneurysmhormones hormone substitutes and hormone antagonistsAdultmedicine.medical_specialtyvascular remodelingThoracic aortic aneurysmYoung Adult03 medical and health sciencesVascular Stiffnessmedicine.arteryInternal medicineAscending aortaAnimalsHumansAgedCell ProliferationAortic Aneurysm Thoracicbusiness.industryleptin antagonistmedicine.diseaseAneurysmAngiotensin II030104 developmental biologyEndocrinologyAnimal Models of Human DiseaseValvular Heart DiseasebusinessJournal of the American Heart Association
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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.

2014

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2-hydroxyglutaric acid (D-2HG). To study the pathophysiological consequences of the accumulation of D-2HG, we generated transgenic mice with conditionally activated IDH2R140Q and IDH2R172K alleles. Global induction of mutant IDH2 expression in adults resulted in dilated cardiomyopathy, white matter abnormalities throughout the central nervous system (CNS), and muscular dystrophy. Embryonic activation of mutant IDH2 resulted in more pronounced ph…

Genetically modified mouseTransgeneMutantCardiomyopathyMice NudeBiologyIDH2Cell LineGlutarateschemistry.chemical_compoundMiceGeneticsmedicineAnimalsHumansMuscular dystrophyMice Inbred BALB CGlycogenGene Expression ProfilingGene Expression Regulation DevelopmentalHeartNeurodegenerative Diseasesmedicine.diseaseMolecular biologyIsocitrate DehydrogenaseIsocitrate dehydrogenasechemistryMutationCardiomyopathiesDevelopmental BiologyResearch PaperGenesdevelopment
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