0000000000591987

AUTHOR

Trevor W. Robbins

showing 3 related works from this author

The Interaction of Person-Affect-Cognition-Execution (I-PACE) model for addictive behaviors: Update, generalization to addictive behaviors beyond int…

2019

We propose an updated version of the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, which we argue to be valid for several types of addictive behaviors, such as gambling, gaming, buying-shopping, and compulsive sexual behavior disorders. Based on recent empirical findings and theoretical considerations, we argue that addictive behaviors develop as a consequence of the interactions between predisposing variables, affective and cognitive responses to specific stimuli, and executive functions, such as inhibitory control and decision-making. In the process of addictive behaviors, the associations between cue-reactivity/craving and diminished inhibitory control contribute to th…

Cognitive Neurosciencemedia_common.quotation_subjectDecision MakingMedizinPrefrontal CortexCravingAffect (psychology)Executive Function03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineddc:150Generalization (learning)mental disordersmedicineHumans0501 psychology and cognitive sciences050102 behavioral science & comparative psychologymedia_commonAddiction05 social sciencesVentral striatumFakultät für Bildungswissenschaften » Institut für Psychologie » Allgemeine Psychologie und SozialpsychologieCognitionModels TheoreticalAmygdalaExecutive functionsBehavior AddictiveInhibition PsychologicalNeuropsychology and Physiological Psychologymedicine.anatomical_structurePsychologieCue reactivityVentral Striatummedicine.symptomPsychology030217 neurology & neurosurgeryCognitive psychologyNeuroscience & Biobehavioral Reviews
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Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists

2011

Rationale Impulsivity is associated with a number of psychiatric disorders, most notably attention deficit/hyperactivity disorder (ADHD). Drugs that augment catecholamine function (e.g. methylphenidate and the selective noradrenaline reuptake inhibitor atomoxetine) have clinical efficacy in ADHD, but their precise mechanism of action is unclear. Objective The objective of this study is to investigate the relative contribution of dopamine (DA) and noradrenaline (NA) to the therapeutic effects of clinically effective drugs in ADHD using rats selected for high impulsivity on the five-choice serial reaction time task (5CSRTT). Methods We examined the effects of direct and indirect DA and NA rec…

MaleImpulsivityQuinpiroleDopamineSerial LearningAtomoxetine HydrochlorideImpulsivityChoice BehaviorPiperazines03 medical and health sciences0302 clinical medicineQuinpiroleDopaminemental disordersAnimals Outbred StrainsReaction TimemedicineAnimalsAttentionOriginal InvestigationPharmacologyPropylaminesMethylphenidateDopaminergicAtomoxetineGBR-12909Adrenergic AgonistsGuanfacineRats030227 psychiatry3. Good healthGuanfacineSumaniroleFive-choice serial reaction time taskAtomoxetine; Dopamine; Five-choice serial reaction time task; GBR-12909; Guanfacine; Impulsivity; Methylphenidate; Noradrenaline; Quinpirole; Sumanirole; Adrenergic Agonists; Animals; Animals Outbred Strains; Atomoxetine Hydrochloride; Attention; Benzimidazoles; Choice Behavior; Dopamine Agonists; Guanfacine; Impulsive Behavior; Male; Methylphenidate; Piperazines; Propylamines; Quinpirole; Rats; Reaction Time; Serial Learning; PharmacologyAnesthesiaDopamine AgonistsImpulsive BehaviorNoradrenalineAtomoxetineMethylphenidateBenzimidazolesmedicine.symptomPsychologyNeuroscience030217 neurology & neurosurgerymedicine.drugAtomoxetine hydrochloride
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The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeki…

2015

Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioi…

Malemedicine.medical_specialtyAlcohol Drinkingmedia_common.quotation_subjectNarcotic AntagonistsDrug-Seeking BehaviorDrug Evaluation PreclinicalReceptors Opioid muPoison controlAlcoholContext (language use)Choice BehaviorNaltrexonechemistry.chemical_compoundSpecies SpecificitymedicineAnimalsPsychiatrymedia_commonPharmacologyDose-Response Relationship DrugAddictionAbstinenceTriazolesNaltrexoneRatsPsychiatry and Mental healthDisease Models AnimalchemistryAlcohol DeterrentsAnesthesiaIndansCommentaryConditioning OperantBlood alcohol contentBlood Alcohol ContentCuesPsychologyAlcohol-Related DisordersReinforcement Psychologymedicine.drugAlcohol DeterrentsNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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