0000000000594673
AUTHOR
Xue Zhang
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.
Familial idiopathic basal ganglia calcification (IBGC) is a genetic condition with a wide spectrum of neuropsychiatric symptoms, including parkinsonism and dementia. Here, we identified mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ancestry, and we observed significantly impaired phosphate transport activity for all assayed PiT2 mutants in Xenopus laevis oocytes. Our results implicate altered phosphate homeostasis in the etiology of IBGC.
Battery characterization via eddy-current imaging with nitrogen-vacancy centers in diamond
Sensitive and accurate diagnostic technologies with magnetic sensors are of great importance for identifying and localizing defects of rechargeable solid batteries in a noninvasive detection. We demonstrate a microwave-free AC magnetometry method with negatively charged NV centers in diamond based on a cross-relaxation feature between NV centers and individual substitutional nitrogen (P1) centers occurring at 51.2 mT. We apply the technique to non-destructive solid-state battery imaging. By detecting the eddy-current-induced magnetic field of the battery, we distinguish a defect on the external electrode and identify structural anomalies within the battery body. The achieved spatial resolut…
In vitroandin vivoenhancement of osteogenic capacity in a synthetic BMP-2 derived peptide-coated mineralized collagen composite
Enhancement of osteogenic capacity was achieved in a mineralized collagen composite, nano-hydroxyapatite/collagen (nHAC), by loading with synthetic peptides derived from BMP-2 residues 32-48 (P17-BMP-2). Rabbit marrow stromal cells (MSCs) were used in vitro to study cell biocompatibility, attachment and differentiation on the mineralized collagen composite by a cell counting kit, scanning electron microscopy (SEM) and real-time reversed transcriptase-polymerase chain reaction analysis (RT-PCR). Optimal peptide dosage (1.0 µg/mL) was obtained by RT-PCR analysis in vitro. In addition, the relative expression level of OPN and OCN was significantly upregulated on P17-BMP-2/nHAC compared with nH…
Improved Bounds on Ultralight Scalar Dark Matter in the Radio-Frequency Range
We present a search for fundamental constant oscillations in the range $20$~kHz-$100$ MHz, that may arise within models for ultralight dark matter (UDM). Using two independent, significantly upgraded optical-spectroscopy apparatus, we achieve up to $\times$1000 greater sensitivity in the search relative to previous work. We report no observation of UDM and thus constrain respective couplings to electrons and photons within the investigated UDM particle mass range $8\cdot 10^{-11}-4\cdot 10^{-7}$ eV. The constraints significantly exceed previously set bounds, and as we show, may surpass in future experiments those provided by equivalence-principle experiments in a specific case regarding the…