0000000000595943

AUTHOR

Sergi Castellano

0000-0002-5819-4210

showing 2 related works from this author

A Revised Timescale for Human Evolution Based on Ancient Mitochondrial Genomes

2013

Summary Background Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate that is approximately half that of previous estimates based on fossil calibration. This result has led to suggestions that major events in human evolution occurred far earlier than previously thought. Results Here, we use mitochondrial genome sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration points for the mitochondrial clock, thus yielding a direct estimate of the mitochondrial substitution rate. Our clock yields mitochondrial divergence times that are in agreement with earlier estimates based on calibration points derived from e…

Mitochondrial DNATime Factorsancient modern humansMolecular Sequence DataPopulationancient modern humans; mitochondrial genome; mitochondrial clockBiologyGenomeArticleGeneral Biochemistry Genetics and Molecular BiologyEvolution Molecular03 medical and health sciences0302 clinical medicineHumanseducationancient DNA Human EvolutionPhylogenyDemography030304 developmental biologyGeneticsHuman mitochondrial molecular clock0303 health scienceseducation.field_of_studyBase SequenceModels GeneticAgricultural and Biological Sciences(all)FossilsGenome HumanBiochemistry Genetics and Molecular Biology(all)HaplotypeHigh-Throughput Nucleotide SequencingBayes TheoremHaplogroup L3mitochondrial clockHaplotypesHuman evolutionmitochondrial genomeGenome MitochondrialLinear ModelsHuman genomeGeneral Agricultural and Biological Sciences030217 neurology & neurosurgeryCurrent Biology
researchProduct

Ancient human genomes suggest three ancestral populations for present-day Europeans

2014

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes1,2,3,4 with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians3, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these popula…

HistoryNeanderthalBiologíaPopulation DynamicsPresent dayGenoma humàGenome//purl.org/becyt/ford/1 [https]Basal (phylogenetics)Settore BIO/13 - Biologia ApplicataHistory AncientGeneticsPrincipal Component Analysiseducation.field_of_study0303 health sciencesGenomeMultidisciplinaryAncient DNA030305 genetics & heredityfood and beveragesAgricultureGenomics3. Good healthEuropeWorkforceCIENCIAS NATURALES Y EXACTASHumanArchaeogeneticsAsiaLineage (genetic)EUROPEOtras Ciencias BiológicasEuropean Continental Ancestry GroupPopulationSettore BIO/08 - ANTROPOLOGIAevolution; EuropeansGenomicsBiologyArticleWhite PeopleAncientGenètica de poblacions humanesHuman originsCiencias Biológicas03 medical and health sciencesHUMAN ORIGINSbiology.animalHumansANCIENT DNA//purl.org/becyt/ford/1.6 [https]educationQuantitative Biology - Populations and EvolutionDenisovan030304 developmental biologyGenetic diversityancient DNA modern DNA Europeans prehistoryGenome HumanPopulations and Evolution (q-bio.PE)biology.organism_classificationAncient DNAEvolutionary biologyFOS: Biological sciencesUpper PaleolithicHuman genomeGENOMICS
researchProduct