0000000000599068

AUTHOR

Markus J. Wilhelm

showing 2 related works from this author

The clinical impact of donor-specific antibodies in heart transplantation.

2018

Donor-specific antibodies (DSA) are integral to the development of antibody-mediated rejection (AMR). Chronic AMR is associated with high mortality and an increased risk for cardiac allograft vasculopathy (CAV). Anti-donor HLA antibodies are present in 3-11% of patients at the time of heart transplantation (HTx), with de novo DSA (predominantly anti-HLA class II) developing post-transplant in 10-30% of patients. DSA are associated with lower graft and patient survival after HTx, with one study suggesting a three-fold increase in mortality in patients who develop de novo DSA (dnDSA). DSA against anti-HLA class II, notably DQ, are at particularly high risk for graft loss. Although detection o…

OncologyGraft Rejectionmedicine.medical_specialty2747 Transplantationmedicine.medical_treatment610 Medicine & health030204 cardiovascular system & hematology030230 surgeryAntibodies03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumans10220 Clinic for SurgeryImmunoadsorptionKidney transplantationHeart transplantationTransplantationbiologybusiness.industryHazard ratioImmunosuppressionmedicine.disease10020 Clinic for Cardiac Surgerybody regionsbiology.proteinHeart TransplantationRituximabPlasmapheresisAntibodybusinessmedicine.drugTransplantation reviews (Orlando, Fla.)
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Early endovascular aneurysm repair after percutaneous coronary interventions

2015

Objective The objective of this study was to report long-term results of early endovascular aortic aneurysm repair after percutaneous coronary intervention (PCI). Methods This was a retrospective analysis of all patients presenting with abdominal aortic aneurysm and coronary artery disease treated during the same hospitalization by endovascular aortic aneurysm repair performed soon after PCI. Primary outcomes were perioperative mortality, perioperative complications, survival after treatment, and freedom from reintervention. Results A total of 20 patients were included, and all completed both procedures. No deaths or abdominal aortic aneurysm ruptures occurred between the PCI and the aortic…

Malemedicine.medical_treatmentCoronary DiseaseComorbidityEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareCoronary artery diseaseAortic aneurysmPostoperative ComplicationsRisk FactorsRetrospective StudieCause of DeathMyocardial infarctionHospital MortalityAged; Aged 80 and over; Aortic Aneurysm Abdominal; Cause of Death; Combined Modality Therapy; Comorbidity; Coronary Disease; Follow-Up Studies; Hospital Mortality; Humans; Italy; Male; Middle Aged; Postoperative Complications; Reoperation; Retrospective Studies; Risk Factors; Survival Rate; Early Medical Intervention; Percutaneous Coronary Intervention; Cardiology and Cardiovascular Medicine; Surgery; Medicine (all)Aged 80 and overMedicine (all)Middle AgedCombined Modality TherapyAbdominal aortic aneurysm2746 SurgerySurvival RateItalycardiovascular systemCardiologyCardiology and Cardiovascular MedicineHumanReoperationmedicine.medical_specialty10216 Institute of Anesthesiology610 Medicine & health2705 Cardiology and Cardiovascular MedicineFollow-Up StudiePercutaneous Coronary InterventionInternal medicineEarly Medical InterventionmedicineHumanscardiovascular diseasesRetrospective StudiesAgedbusiness.industryRisk FactorPercutaneous coronary interventionPerioperativemedicine.disease10020 Clinic for Cardiac SurgerySurgeryConventional PCISurgeryPostoperative ComplicationbusinessFollow-Up StudiesAortic Aneurysm Abdominal
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