0000000000599975

AUTHOR

Antonio A. Vázquez

showing 1 related works from this author

Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

2013

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7′8-dihydro-2′-deoxyguanosine (8-oxo-dG) in human gastric carcinoma (HGC) samples and compared the results with normal tissue from the same patients. We also analyzed 8-oxo-dG in peripheral mononuclear cells (PMNC) and urine from healthy control subjects and in affected patients in the basal state and one, three, six, nine and twelve months after tumor resection. The levels of DNA repair enzyme mRNA expression (hOGG1, RAD51, MUYTH and MTH1) were determined in tumor specimens and compared with normal mucosa. Tumor specimens exhibited i…

medicine.medical_specialtyPathologyDNA damageDNA repair8-oxo-dGBiologymedicine.disease_causePeripheral blood mononuclear cellArticleCatalysisInorganic Chemistrychemistry.chemical_compoundInternal medicinemedicine8-oxo-dG; DNA repair enzymes; gastric cancer; oxidative stress; tumor markeroxidative stressDeoxyguanosinePhysical and Theoretical ChemistryMolecular BiologySpectroscopyTumor markergastric cancerOrganic ChemistryGeneral MedicineGlutathioneMalondialdehydeComputer Science ApplicationsEndocrinologyDNA repair enzymeschemistrytumor markerOxidative stressInternational Journal of Molecular Sciences; Volume 14; Issue 2; Pages: 3467-3486
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