0000000000600392

AUTHOR

Jan Kool

showing 3 related works from this author

Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis

2020

ObjectiveTo examine acute (single-bout) and training effects of high-intensity interval training (HIIT) vs standard exercise therapy (moderate continuous training [MCT]) on plasma neurofilament light chain (pNfL) and kynurenine (KYN) pathway of tryptophan degradation metabolites in persons with multiple sclerosis (pwMS).MethodsSixty-nine pwMS (Expanded Disability Status Scale score 3.0–6.0) were randomly assigned to a HIIT or an MCT group. Changes in pNfL and KYN pathway metabolites measured in blood plasma were assessed before, after, and 3 hours after the first training session as well as after the 3-week training intervention.ResultsAcute exercise reduced pNfL and increased the KYN pathw…

AdultMalemedicine.medical_specialtyMultiple SclerosisKynurenine pathway41132NeuroprotectionArticleInterval trainingchemistry.chemical_compoundKynurenic acidNeurofilament ProteinsInternal medicineBlood plasmamedicineHumansSingle-Blind MethodProspective StudiesExerciseKynurenineAgedAged 80 and overExpanded Disability Status Scalebusiness.industryMultiple sclerosisTryptophanMiddle Agedmedicine.diseaseExercise TherapyEndocrinologyNeurologychemistryFemaleNeurology (clinical)businessKynurenineNeurology - Neuroimmunology Neuroinflammation
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Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised…

2020

BackgroundLow back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise.MethodsIn parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison characteristic…

MINIMAL INTERVENTIONMOTOR CONTROL EXERCISESMedical and Health SciencesBody Mass Index0302 clinical medicineEngineeringGRADED ACTIVITYOrthopedics and Sports MedicineMass index030212 general & internal medicineRandomized Controlled Trials as TopicGENERAL EXERCISEexercise rehabilitationPATIENT-LEVELGeneral MedicineLow back painPeer reviewExercise TherapyMeta-analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingmedicine.symptommedicine.medical_specialtyExercise treatmentPhysical Therapy Sports Therapy and Rehabilitationintervention effectivenessFUNCTION-CENTERED REHABILITATIONCLINICAL-TRIALEducationHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesRC925SDG 3 - Good Health and Well-beingmedicineHumansFLEXION-DISTRACTIONProtocol (science)business.industryIndividual participant dataChronic Low Back Pain IPD Meta-Analysis GroupECOLOGICAL BIASSYSTEMATIC REVIEWSClinical trialmeta-analysislower backPhysical therapybusinessLow Back Pain030217 neurology & neurosurgerySport Sciences
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Exercise treatment effect modifiers in persistent low back pain : an individual participant data meta-analysis of 3514 participants from 27 randomise…

2020

Background: Low back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise. Methods: In parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison character…

meta-analysislower backselkäsairaudetexercise rehabilitationmeta-analyysikrooninen kipukuntoutusintervention effectivenessliikuntahoito
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