Author: Paolo Dabrilli

0000000000606959

AUTHOR

Paolo Dabrilli

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Oncofetal gene SALL4 and prognosis in cancer: A systematic review with meta-analysis

2016

The Spalt-Like Transcription Factor 4 (SALL4) oncogene plays a central function in embryo-fetal development and is absent in differentiated tissues. Evidence suggests that it can be reactivated in several cancers worsening the prognosis. We aimed at investigating the risk associated with SALL4 reactivation for all-cause mortality and recurrence in cancer using the current literature. A PubMed and SCOPUS search until 1st September 2016 was performed, focusing on perspective studies reporting prognostic parameters in cancer data. In addition, 17 datasets of different cancer types from The Cancer Genome Atlas were considered. A total of 9,947 participants across 40 cohorts, followed-up for abo…

0301 basic medicineOncologymedicine.medical_specialtyPediatricsmedicine.medical_treatmentDiseaseTargeted therapySALL4; cancer; meta-analysis; prognosis; targeted therapy; Humans; Neoplasms; Prognosis; Transcription FactorsCancer; Meta-analysis; Prognosis; SALL4; Targeted therapy; Oncology03 medical and health sciences0302 clinical medicineSALL4Internal medicineNeoplasmsmedicinecancerHumansSALL4 cancer prognosis meta-analysis targeted therapySALL4business.industryConfoundingHazard ratiotargeted therapyConfidence intervaleye diseases3. Good healthmeta-analysis030104 developmental biologyOncology030220 oncology & carcinogenesisMeta-analysisRelative riskprognosisbusinessResearch PaperTranscription Factors

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