0000000000608917

AUTHOR

R. Terg

showing 2 related works from this author

FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin…

2011

Background & Aims EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon–alfa/ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients. Methods Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV)…

education.field_of_studymedicine.medical_specialtyHepatologymedicine.diagnostic_testbusiness.industryFibroTestRibavirinPopulationvirus diseasesAlpha interferonHepatitis Cmedicine.diseaseGastroenterologydigestive system diseaseschemistry.chemical_compoundchemistryInternal medicineImmunologyBiopsyMedicinebusinesseducationViral loadInterferon alfamedicine.drugJournal of Hepatology
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin…

2010

EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon-alfa/ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients.Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed us…

AdultLiver CirrhosisMaleBiopsyFibrotestInterferon-alphaAlanine TransaminaseHepatitis C ChronicInterferon alpha-2Middle AgedPrognosisRecombinant ProteinsPolyethylene GlycolsFatty LiverRibavirinHumansDrug Therapy CombinationFemaleProspective Studies
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