Author: Anastasia Piyanova

0000000000609573

AUTHOR

Anastasia Piyanova

showing 1 related works from this author

Age-related changes in the endocannabinoid system in the mouse hippocampus.

2015

Previous studies have demonstrated that the endocannabinoid system significantly influences the progression of brain ageing, and the hippocampus is one of the brain regions most vulnerable to ageing and neurodegeneration. We have further examined age-related changes in the hippocampal endocannabinoid system by measuring the levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in young and old mice from two different mouse strains. We found a decrease in 2-AG but not AEA levels in aged mice. In order to identify the cause for 2-AG level changes, we investigated the levels of several enzymes that contribute to synthesis and degradation of 2-AG in the hippocampus. We found a selective …

medicine.medical_specialtyAgingPolyunsaturated Alkamides2-ArachidonoylglycerolHippocampusmetabolism [Hippocampus]Arachidonic AcidsHippocampal formationBiologyHippocampusGlycerideschemistry.chemical_compoundMicepathology [Aging]Internal medicinemetabolism [Arachidonic Acids]medicineanandamideAnimalsglyceryl 2-arachidonateddc:610metabolism [Aging]NeurodegenerationAnandamidemedicine.diseasemetabolism [Endocannabinoids]Endocannabinoid systemMonoacylglycerol lipaseLipoprotein Lipasepathology [Hippocampus]metabolism [Polyunsaturated Alkamides]EndocrinologychemistryAgeingphysiopathology [Hippocampus]lipids (amino acids peptides and proteins)metabolism [Lipoprotein Lipase]metabolism [Glycerides]Developmental BiologyEndocannabinoidsMechanisms of ageing and development

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