0000000000609861
AUTHOR
Perez A.
Search for di-muon decays of a low-mass Higgs boson in radiative decays of the Gamma(1S)
We search for di-muon decays of a low-mass Higgs boson (A(0)) produced in radiative Gamma(1S) decays. The Gamma(1S) sample is selected by tagging the pion pair in the Gamma(2S, 3S) -> pi(+)pi(-) Gamma(1S) transitions, using a data sample of 92.8 x 10(6) Gamma(2S) and 116.8 x 10(6) Gamma(3S) events collected by the BABAR detector. We find no evidence for A(0) production and set 90% confidence level upper limits on the product branching fraction B(Gamma(1S) -> gamma Lambda(0)) x B(Lambda(0)->mu(+)mu(-)) in the range of (0.28 - 9.7) x 10(-6) for 0.212 gamma Lambda(0), Lambda(0) -> mu(+)mu(-) to set limits on the effective coupling of the b quark to the Lambda(0).
BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: Looking for the hidden meaning
Hereditary breast and ovarian cancer syndrome is caused by germline mutations in BRCA1/2 genes. These genes are very large and their mutations are heterogeneous and scattered throughout the coding sequence. In addition to the above-mentioned mutations, variants of uncertain/unknown significance (VUSs) have been identified in BRCA genes, which make more difficult the clinical management of the patient and risk assessment. In the last decades, several laboratories have developed different databases that contain more than 2000 variants for the two genes and integrated strategies which include multifactorial prediction models based on direct and indirect genetic evidence, to classify the VUSs a…