0000000000609861

AUTHOR

Perez A.

showing 2 related works from this author

Search for di-muon decays of a low-mass Higgs boson in radiative decays of the Gamma(1S)

2013

We search for di-muon decays of a low-mass Higgs boson (A(0)) produced in radiative Gamma(1S) decays. The Gamma(1S) sample is selected by tagging the pion pair in the Gamma(2S, 3S) -> pi(+)pi(-) Gamma(1S) transitions, using a data sample of 92.8 x 10(6) Gamma(2S) and 116.8 x 10(6) Gamma(3S) events collected by the BABAR detector. We find no evidence for A(0) production and set 90% confidence level upper limits on the product branching fraction B(Gamma(1S) -> gamma Lambda(0)) x B(Lambda(0)->mu(+)mu(-)) in the range of (0.28 - 9.7) x 10(-6) for 0.212 gamma Lambda(0), Lambda(0) -> mu(+)mu(-) to set limits on the effective coupling of the b quark to the Lambda(0).

Nuclear and High Energy PhysicsParticle physicsElectron–positron annihilationAstrophysics::High Energy Astrophysical PhenomenaQuarkonium01 natural sciencesBottom quarkHigh Energy Physics - ExperimentNuclear physicsPion0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]010306 general physicsPhysicsMuon010308 nuclear & particles physicsBranching fractionHigh Energy Physics::PhenomenologyBABAR detectorQuarkoniumHEP3. Good healthPACS: 12.60.Fr 12.60.Jv 13.20.Gd 13.35.BvBaBarHiggs bosonLeptonic decaysFísica nuclearHigh Energy Physics::ExperimentMinimal Supersymmetric Standard Model
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BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: Looking for the hidden meaning

2021

Hereditary breast and ovarian cancer syndrome is caused by germline mutations in BRCA1/2 genes. These genes are very large and their mutations are heterogeneous and scattered throughout the coding sequence. In addition to the above-mentioned mutations, variants of uncertain/unknown significance (VUSs) have been identified in BRCA genes, which make more difficult the clinical management of the patient and risk assessment. In the last decades, several laboratories have developed different databases that contain more than 2000 variants for the two genes and integrated strategies which include multifactorial prediction models based on direct and indirect genetic evidence, to classify the VUSs a…

BRCA2 ProteinOvarian NeoplasmsBRCA1 ProteinBreast NeoplasmsHematologyBRCA1Multifactorial prediction modelBRCA2Risk AssessmentVariants of Uncertain SignificanceVUSOncologyMutationHereditary Breast and Ovarian Cancer SyndromeHumansFemaleGenetic Predisposition to DiseaseGerm-Line MutationCritical Reviews in Oncology/Hematology
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