0000000000610093
AUTHOR
Zhi Hu
showing 2 related works from this author
An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
2008
Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy–based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor–positive (34.5%) and HER2-positive (22.7%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor–positive cancers. Unlike AKT1 mutations that were absent …
On Hodge theory for the generalized geometry (I)
2013
Abstract We first investigate the linear Dirac structure from the viewpoint of a mixed Hodge structure. Then we discuss a Hodge-decomposition-type theorem for the generalized Kahler manifold and study the moduli space of a generalized weak Calabi–Yau manifold. We present a holomorphic anomaly equation and a one-loop partition function in a topological B-model under the generalized geometric context.