0000000000611024

AUTHOR

Almudena Cubells

showing 2 related works from this author

A population-based screening for hepatitis C antibodies and active infection using a point-of-care test in a low prevalence area

2020

Background Data on the true prevalence of hepatitis C virus (HCV) infection in the general population is essential. We evaluated a program implementing free universal HCV screening using a non-invasive point-of-care test (POCT) (OraQuick-HCV rapid test) in oral fluid in an urban area in Valencia, South-Eastern Spain. Methods A cross-sectional study was performed during 2015–2017. Free HCV screening was offered by regular mail to 11,500 individuals aged 18 and over, randomly selected from all census residents in the Health Department. All responding participants filled in a questionnaire about HCV infection risk factors and were tested in their tertiary Hospital. In those with a positive POC…

MaleRNA virusesSustained Virologic ResponseUrban PopulationEpidemiologyPhysiologyCross-sectional studyHepacivirusmedicine.disease_causeBiochemistryGeographical locations0302 clinical medicineRisk FactorsImmune PhysiologyPrevalence030212 general & internal medicineEnzyme-Linked ImmunoassaysYoung adultPathology and laboratory medicineAged 80 and overResponse rate (survey)education.field_of_studyImmune System ProteinsMultidisciplinaryHepatitis C virusQRMiddle AgedMedical microbiologyHepatitis CEuropeVirusesRNA ViralMedicineFemale030211 gastroenterology & hepatologyStandardized ratePathogensResearch ArticleAdultmedicine.medical_specialtyAdolescentPoint-of-Care SystemsScienceHepatitis C virusPoint-of-care testingImmunologyPopulationResearch and Analysis MethodsAntiviral AgentsMicrobiologyAntibodiesYoung Adult03 medical and health sciencesInternal medicinemedicineHumansEuropean UnionRisk factorImmunoassayseducationAgedMedicine and health sciencesBiology and life sciencesFlavivirusesbusiness.industryOrganismsViral pathogensProteinsHepatitis C AntibodiesFibrosisHepatitis virusesMicrobial pathogensHealth CareCross-Sectional StudiesSpainMedical Risk FactorsImmunologic TechniquesInterferonsPeople and placesbusinessDevelopmental BiologyPLOS ONE
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Cytomegalovirus reactivation in liver transplant recipients due to hepatitis C cirrhosis is associated with higher cardiovascular risk - an observati…

2017

The association between cytomegalovirus (CMV) reactivation and cardiovascular risk has been reported in solid organ transplant populations; however, it has yet to be assessed in liver transplantation (LT). We aim to evaluate whether CMV reactivation is associated with cardiovascular events (CVE) in HCV-LT patients. LT patients (2010 and 2014) due to HCV cirrhosis were included. Clinically significant CMV (CS-CMV) was defined as viral load (VL) >5000 copies/ml, need of therapy or CMV disease. Baseline variables and endpoint measures (CVE, survival, severe recurrent hepatitis C, de novo tumors, and diabetes) were collected. One hundred and forty patients were included. At LT, a history of AHT…

Liver CirrhosisMalemedicine.medical_specialtyCirrhosismedicine.medical_treatmentCongenital cytomegalovirus infectionCytomegalovirus030230 surgeryLiver transplantationGastroenterology03 medical and health sciences0302 clinical medicineRisk FactorsDiabetes mellitusInternal medicinemedicineHumansAgedProportional Hazards ModelsRetrospective StudiesImmunosuppression TherapyTransplantationProportional hazards modelbusiness.industryvirus diseasesRetrospective cohort studyHepatitis CMiddle AgedViral Loadmedicine.diseaseHepatitis CTissue DonorsLiver TransplantationCardiovascular DiseasesCytomegalovirus Infections030211 gastroenterology & hepatologyFemalebusinessViral loadGlomerular Filtration RateTransplant international : official journal of the European Society for Organ Transplantation
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