0000000000612273

AUTHOR

Agostinho Antunes

showing 3 related works from this author

The swinholide biosynthesis gene cluster from a terrestrial cyanobacterium, Nostoc sp. strain UHCC 0450

2017

ABSTRACT Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to be produced by symbiotic bacteria. Misakinolide, a structural variant of swinholide, was recently demonstrated to be the product of a symbiotic heterotrophic proteobacterium. Here, we report the production of swinholide A by an axenic strain of the terrestrial cyanobacterium Nostoc sp. strain UHCC 0450. We located the 85-kb trans -AT polyketide synthase (PKS) swinholide biosynthesis gene cluster from a draft genome of Nostoc sp. UHCC 0450. The swinholide …

0301 basic medicinemarine environmentterrestrial environmentDIVERSITYcyanobacteria01 natural sciencesApplied Microbiology and BiotechnologyBiochemistryTrans-AT PKSMARINE CYANOBACTERIAGene clusterEnvironmental MicrobiologyskeletonSPONGE THEONELLA-SWINHOEISpotlightAxenicNostocgene transfertoxinSwinholide1183 Plant biology microbiology virologyPhylogenychemistry.chemical_classificationEcologybiologyAnabaena sp.ChemistryAnabaenaHorizontal gene transferKetonesbacteriumenzyme activityphylogeneticsINSIGHTSBiochemistryMultigene Familyhorizontal gene transferscytophycinScandium compoundspolyketidesBiotechnologyNostoctrans-AT PKSScytophycinNONRIBOSOMAL PEPTIDEBiosynthesisCyanobacteriaswinholideCYTOTOXIC DIMERIC MACROLIDES03 medical and health sciencesPolyketideBacterial ProteinsNonribosomal peptidecyanobacteriumPolyketide synthaseProteobacteriaCONGENERSCandidatus Entotheonellabovine spongiform encephalopathygeneNostoc sp.Bacteriacatalysis010405 organic chemistryProteinsSequence Analysis DNAbiology.organism_classificationActin cytoskeletonAnabaenaEVOLUTION"Candidatus Entotheonella"0104 chemical sciencesenzymeNATURAL-PRODUCT DISCOVERY030104 developmental biologyGenesPolyketidesbiology.proteingene expressionbacteria“Candidatus Entotheonella”Theonella sp.Marine ToxinsPolyketide SynthasesFood Sciencecatalyst
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The era of reference genomes in conservation genomics

2022

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics.

QH301 Biology580 Plants (Botany)Genetics -- ResearchEvolutionsbiologibiodiversity conservation; conservation genetics; ERGA; European Reference Genome AtlasConservation genetics; Biodiversity conservation; European Reference Genome Atlas; ERGAAnimal genome mappingudc:630*1GenomeGEERGA[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE][SDE.BE.BIOD]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.biodERGA ; Biodiversity [MeSH] ; Genomics [MeSH] ; Ecology Evolution Behavior and Systematics ; conservation genetics ; Genome [MeSH] ; biodiversity conservation ; European Reference Genome Atlas3rd-DASGenomicsBiodiversityreferenčni genomi[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM][SDE.BE.BEC]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.becChemistry10121 Department of Systematic and Evolutionary BotanygenomikaGE Environmental Sciences:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]biodiverzitetaSettore BIO/18 - GENETICAeducationQH426 GeneticsQH301European Reference Genome AtlasVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470[SDE.BE.EVO]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.evoGeneticsconservation genetics ; biodiversity conservation ; European Reference Genome Atlas ; ERGAgenomi10211 Zurich-Basel Plant Science CenterGenomesGenetikBiologyQH426Ecology Evolution Behavior and SystematicsEvolutionary BiologyBiodiversity conservation; Conservation genetics; European Reference Genome AtlasAmbientaleEcologíaGenética1105 Ecology Evolution Behavior and Systematicsconservation geneticsWildlife conservation570 Life sciences; biologyHuman medicinebiodiversity conservationAnimal genetics[SDE.BE]Environmental Sciences/Biodiversity and EcologyGenètica
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The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450

2018

Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to be produced by symbiotic bacteria. Misakinolide, a structural variant of swinholide, was recently demonstrated to be the product of a symbiotic heterotrophic proteobacterium. Here, we report the production of swinholide A by an axenic strain of the terrestrial cyanobacterium Nostoc sp. strain UHCC 0450. We located the 85-kb trans-AT polyketide synthase (PKS) swinholide biosynthesis gene cluster from a draft genome of Nostoc sp. UHCC 0450. The swinholide and misaki…

trans-AT PKSbacteriaEntotheonellaNostocscytophycinhorisontaalinen geeninsiirtosyanobakteeritpolyketides
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