0000000000613525

AUTHOR

Alexander Bachmann

showing 3 related works from this author

Laparoscopic adrenalectomy in urological centres - the experience of the German Laparoscopic Working Group

2011

Study Type – Practice patterns (retrospective cohort) Level of Evidence 2b OBJECTIVE • To evaluate the safety and feasibility of laparoscopic adrenalectomy (LA) performed in several German centres with different laparoscopic experience, as LA has become the gold-standard approach for benign surgical adrenal disorders; however, for solitary metastasis or primary adrenal cancer its precise role is uncertain. PATIENTS AND METHODS • The data of 363 patients who underwent a LA were prospectively collected in 23 centres. • All centres were stratified into three groups according to their experience: group A ( 20 LAs/year). • In all, 15 centres used a transperitoneal approach, four a retroperitonea…

medicine.medical_specialtymedicine.diagnostic_testAdrenal disorderLaparoscopic adrenalectomybusiness.industryUrologyAdrenalectomymedicine.medical_treatmentRetrospective cohort studyPerioperativeSurgerymedicineProspective cohort studybusinessLaparoscopyComplicationBJU International
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EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction.

2013

To present a summary of the 2013 version of the European Association of Urology guidelines on the treatment and follow-up of male lower urinary tract symptoms (LUTS). We conducted a literature search in computer databases for relevant articles published between 1966 and 31 October 2012. The Oxford classification system (2001) was used to determine the level of evidence for each article and to assign the grade of recommendation for each treatment modality. Men with mild symptoms are suitable for watchful waiting. All men with bothersome LUTS should be offered lifestyle advice prior to or concurrent with any treatment. Men with bothersome moderate-to-severe LUTS quickly benefit from α1-blocke…

Malemedicine.medical_specialtyPhosphodiesterase Inhibitorsmedicine.medical_treatmentUrologyUrologyProstatic HyperplasiaMuscarinic AntagonistsSeverity of Illness Indexchemistry.chemical_compound5-alpha Reductase InhibitorsLower Urinary Tract SymptomsLower urinary tract symptomsmedicineNocturiaHumansWatchful WaitingTransurethral resection of the prostateUrinary retentionProstatectomybusiness.industryTransurethral Resection of Prostatemedicine.diseaseDutasterideTreatment OutcomechemistryAdrenergic alpha-1 Receptor AntagonistsUrological AgentsProstate surgeryStentsmedicine.symptombusinessUrinary CatheterizationRisk Reduction BehaviorWatchful waitingEuropean urology
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An Anti-Ubiquitin Antibody Response in Transitional Cell Carcinoma of the Urinary Bladder

2015

BackgroundTo use combinatorial epitope mapping ("fingerprinting") of the antibody response to identify targets of the humoral immune response in patients with transitional cell carcinoma (TCC) of the bladder.MethodsA combinatorial random peptide library was screened on the circulating pool of immunoglobulins purified from an index patient with a high risk TCC (pTa high grade plus carcinoma in situ) to identify corresponding target antigens. A patient cohort was investigated for antibody titers against ubiquitin.ResultsWe selected, isolated, and validated an immunogenic peptide motif from ubiquitin as a dominant epitope of the humoral response. Patients with TCC had significantly higher anti…

medicine.medical_treatmentScienceUrinary Bladderurologic and male genital diseasesEpitopeImmune systemAntigenmedicineHumansddc:610Carcinoma Transitional CellMultidisciplinarybiologybusiness.industryUbiquitinQAntibody titerRImmunotherapymedicine.diseaseTiterTransitional cell carcinomaUrinary Bladder NeoplasmsImmunologyAntibody Formationbiology.proteinMedicineAntibodybusinessEpitope MappingResearch ArticlePLoS ONE
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