0000000000614275

AUTHOR

Tania Pascual

showing 2 related works from this author

Dynamics of Torque Teno virus plasma DNAemia in allogeneic stem cell transplant recipients

2017

Abstract Background Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Objectives We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. Study design Retrospective single-center observational study including 72 allo-HSCT patients. Plasma TTV DNA loads were quantified before initiating the conditioning regimen and at different time-points after transplant by real-time PCR. White blood cells (WBC) and absolute lymphocyte counts (ALC) were measured by flow cytometry.…

0301 basic medicineAdultMaleHomologousTorque teno virusAdolescentLymphocyteAllogeneic hematopoietic stem cell transplantation (Allo-HSCT); Immune reconstitution; Torque Teno virus (TTV); TTV DNAemia; Adolescent; Adult; Aged; DNA Virus Infections; DNA Viral; Female; Humans; Immunocompromised Host; Leukocyte Count; Male; Middle Aged; Retrospective Studies; Torque teno virus; Transplantation Homologous; Viral Load; Viremia; Young Adult; Hematopoietic Stem Cell Transplantation; Virology; Infectious Diseases030106 microbiologyTTV DNAemiaFlow cytometry03 medical and health sciencesImmunocompromised HostLeukocyte CountYoung AdultVirologyMedicineTransplantation HomologousHumansIn patientViralViremiaProspective cohort studyAgedRetrospective StudiesTorque teno virusTransplantationmedicine.diagnostic_testbusiness.industryHematopoietic Stem Cell TransplantationDNAImmune reconstitutionMiddle AgedViral LoadDNA Virus Infectionssurgical procedures operative030104 developmental biologymedicine.anatomical_structureInfectious DiseasesAllogeneic hematopoietic stem cell transplantation (Allo-HSCT); Immune reconstitution; Torque Teno virus (TTV); TTV DNAemia; Adolescent; Adult; Aged; DNA Virus Infections; DNA; Viral; Female; Humans; Immunocompromised Host; Leukocyte Count; Male; Middle Aged; Retrospective Studies; Torque teno virus; Transplantation; Homologous; Viral Load; Viremia; Young Adult; Hematopoietic Stem Cell Transplantation; Virology; Infectious DiseasesImmunologyDNA ViralAllogeneic hematopoietic stem cell transplantation (Allo-HSCT)FemaleAllogeneic hematopoietic stem cell transplantStem cellImmunocompetencebusinessTorque Teno virus (TTV)
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Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser…

2020

Abstract Introduction To assess the potential added value of rapid MALDI-TOF MS-based identification of bacteria in positive blood cultures to the information provided by Gram staining for adequate empirical antibiotic treatment adjustments in patients with bloodstream infections (BSI). Methods We conducted a retrospective, single-center, pre-post quasi-experimental study. In the pre-MALDI-TOF MS phase of the study antibiotic adjustments were made on the basis of Gram stain results, whereas in the MALDI-TOF MS phase they were based on information provided by Gram staining and MALDI-TOF MS results. No antimicrobial stewardship program for BSI was in place within the study period. Antibiotic …

0301 basic medicineMicrobiology (medical)EnterobacterialesBacillimedicine.medical_specialtymedicine.drug_class030106 microbiologyAntibioticsBacteremialaw.invention03 medical and health sciences0302 clinical medicinelawSepsisInternal medicinemedicineHumansAntimicrobial stewardshipPharmacology (medical)Blood culture030212 general & internal medicineRetrospective StudiesBacteriaStaining and Labelingbiologymedicine.diagnostic_testbusiness.industryLasersbiology.organism_classificationmedicine.diseaseAnti-Bacterial AgentsInfectious DiseasesGram stainingSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationBacteremiabusinessBacteriaJournal of Infection and Chemotherapy
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