0000000000614301

AUTHOR

Cecilia Beatrice Chighizola

showing 2 related works from this author

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications

2018

Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…

lcsh:Immunologic diseases. Allergy0301 basic medicineImmunologyComplementMiscarriagesAnti-beta2 glycoprotein I antibodieInflammationMiscarriagePathogenesis03 medical and health sciences0302 clinical medicineImmune systemAntiphospholipid syndromeimmune system diseasesAntiphospholipid syndromeMedicineImmunology and AllergyAnimal model030203 arthritis & rheumatologyAutoimmune diseaseInflammationbusiness.industryAutoantibodyThrombosismedicine.diseaseComplement (complexity)Complement systemAnimal models030104 developmental biologyAnti-beta2 glycoprotein I antibodiesPerspectiveThrombosiImmunologyAnimal models; Anti-beta2 glycoprotein I antibodies; Antiphospholipid syndrome; Complement; Inflammation; Miscarriages; Therapy; Thrombosis; Immunology and Allergy; ImmunologyTherapymedicine.symptomlcsh:RC581-607businessFrontiers in Immunology
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The AutoInflammatory Diseases Alliance Registry of monogenic autoinflammatory diseases

2022

ObjectiveThe present manuscript aims to describe an international, electronic-based, user-friendly and interoperable patient registry for monogenic autoinflammatory diseases (mAIDs), developed in the contest of the Autoinflammatory Diseases Alliance (AIDA) Network.MethodsThis is an electronic platform, based on the Research Electronic Data Capture (REDCap) tool, used for real-world data collection of demographics, clinical, laboratory, instrumental and socioeconomic data of mAIDs patients. The instrument has flexibility, may change over time based on new scientific acquisitions, and communicate potentially with other similar registries; security, data quality and data governance are corner …

RegistrySettore MED/38 - Pediatria Generale E SpecialisticaSettore MED/16 - REUMATOLOGIAautoinflammatory diseaseprecision medicineAutoinflammatory diseasesrare diseasesHuman medicinepersonalized medicineGeneral Medicinerare diseases.autoinflammatory diseases; international registry; personalized medicine; precision medicine; rare diseasesinternational registry
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