0000000000615461

AUTHOR

G. Hofman

showing 6 related works from this author

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

2021

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

MaleCOVID-19 Vaccinesafe surgery; vaccination modelling; COVID-19Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]MULTICENTERComorbidity030230 surgery0302 clinical medicinephase 3 clinical trial (topic)Case fatality rateProspective StudiesSARS-CoV-2 Vaccination Safe surgeryCOVID-19/epidemiologySARS-CoV-2 ; vaccination ; safe surgeryeducation.field_of_studycase fatality rateVaccinationVaccinationAdolescent; Adult; Aged; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Postoperative Complications; Preoperative Period; Prospective Studies; SARS-CoV-2; Vaccination; Young Adulthealth care policyElective Surgical Procedures030220 oncology & carcinogenesisvaccination modellingPreoperative PeriodCOVID-19; SARS-CoV-2; cancer; vaccination; outcome; mortality; infection; modellingCohort studyprospective studyHumanmedicine.medical_specialtyArticle03 medical and health sciencesSARS-CoV-2 vaccinationSDG 3 - Good Health and Well-beingCOVID-19 Vaccines/pharmacologyHumansVaccination/methodsElective surgeryeducationAgedScience & TechnologyElective Surgical Procedureadult; aged; Article; cancer grading; cancer surgery; case fatality rate; computer assisted tomography; elective surgery; female; follow up; health care policy; human; incidence; infection rate; infection risk; major clinical study; male; middle aged; mortality; outcome assessment; phase 3 clinical trial (topic); preoperative care; prospective study; sensitivity analysis; seroprevalence; Severe acute respiratory syndrome coronavirus 2; vaccination; young adult; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Postoperative Complications; Preoperative Period; SARS-CoV-2; Vaccination; surgery.Cura preoperatòriamajor clinical studymortalityinfectionProspective StudieincidenceSurgeryHuman medicinePostoperative Complication610 Medizin und GesundheitAcademicSubjects/MED00910Settore MED/18 - CHIRURGIA GENERALESettore MED/29 - CHIRURGIA MAXILLOFACCIALEcomputer assisted tomographyESTUDOS PROSPECTIVOSsurgerysafe surgeryPostoperative Complicationssensitivity analysisSevere acute respiratory syndrome coronavirus 2preoperative careVacunacióProspective cohort studyseroprevalenceIncidence (epidemiology)covidElective Surgical Procedures/methodsMiddle Agedcancer gradingCOVID vaccinationoutcome/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingSARS-CoV-2; vaccination; surgeryOriginal ArticleFemalecancer surgeryAcademicSubjects/MED00010Life Sciences & BiomedicineAdultCOVID-19 VaccinesAdolescentinternational prospective cohort studyPostoperative Complications/prevention & controlPopulationinfection rateSARS-CoV-2/immunologyNOmodellingYoung Adultmedicinefollow upcancerddc:610infection riskoutcome assessmentLS7_4business.industrySARS-CoV-2Number needed to vaccinatePreoperative careCOVID-193126 Surgery anesthesiology intensive care radiologySettore MED/18Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]elective surgeryEmergency medicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyThe British Journal of Surgery
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Search for signatures of magnetically-induced alignment in the arrival directions measured by the Pierre Auger Observatory

2011

We present the results of an analysis of data recorded at the Pierre Auger Observatory in which we search for groups of directionally-aligned events (or ‘multiplets’) which exhibit a correlation between arrival direc- tion and the inverse of the energy. These signatures are expected from sets of events coming from the same source after having been deflected by intervening coherent magnetic fields. The observation of several events from the same source would open the possibility to accurately reconstruct the position of the source and also measure the integral of the component of the magnetic field orthogonal to the trajectory of the cos- mic rays. We describe the largest multiplets found an…

[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]Field (physics)Astronomyultra-high energy cosmic rays; Pierre Auger Observatory; arrival directionsFOS: Physical sciencesCosmic rayAstrophysics01 natural sciencesCosmic RayAugerPosition (vector)0103 physical sciencesFIELDPierre auger observatory010303 astronomy & astrophysicsUltra-high energy cosmic rayDETECTORCiencias ExactasHigh Energy Astrophysical Phenomena (astro-ph.HE)Pierre Auger ObservatoryPhysicsArrival directions010308 nuclear & particles physics[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]PhysicsIsotropyFísicaAstronomy and AstrophysicsASTROFÍSICAUltra-high energy cosmic raysMagnetic fieldExperimental High Energy PhysicsData analysisComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFísica nuclearAstrophysics - High Energy Astrophysical Phenomena[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]RAIOS CÓSMICOSArrival directionUltra-High Energy Cosmic Ray
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The Fluorescence Detector of the Pierre Auger Observatory

2010

The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It combines a surface array to measure secondary particles at ground level together with a fluorescence detector to measure the development of air showers in the atmosphere above the array. The fluorescence detector comprises 24 large telescopes specialized for measuring the nitrogen fluorescence caused by charged particles of cosmic ray air showers. In this paper we describe the components of the fluorescence detector including its optical system, the design of the camera, the electronics, and the systems for relative and absolute calibration. We also discuss the operation and the monitoring of the detecto…

Physics::Instrumentation and DetectorsAstronomyAUGERPIERRE7. Clean energy01 natural sciencesAugerFluorescence detectorData acquisitionDEPENDENCEATMOSPHERIC MULTIPLE-SCATTERINGInstrumentationPhysicsDetectorAstrophysics::Instrumentation and Methods for AstrophysicsCOSMIC-RAYSUltra High Energy Cosmic RayCharged particleLIGHTSIMULATIONComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFísica nuclearAstrophysics - Instrumentation and Methods for AstrophysicsAUGERNuclear and High Energy Physics[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Astrophysics::High Energy Astrophysical PhenomenaMeasure (physics)FOS: Physical sciencesCosmic rayEXTENSIVE AIR-SHOWERSENERGIAFluorescence spectroscopyOptics0103 physical sciencesCosmic rays; Fluorescence detectorRECONSTRUCTION010306 general physicsInstrumentation and Methods for Astrophysics (astro-ph.IM)Cosmic raysPierre Auger ObservatoryPIERRE010308 nuclear & particles physicsbusiness.industryFísicaULTRA-HIGH ENERGY[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Experimental High Energy PhysicsPierre Auger observatoryCAPABILITIESHigh Energy Physics::Experimentbusiness
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Search for First Harmonic Modulation in the Right Ascension Distribution of Cosmic Rays Detected at the Pierre Auger Observatory

2011

We present the results of searches for dipolar-type anisotropies in different energy ranges above 2.5 × 1017 eV with the surface detector array of the Pierre Auger Observatory, reporting on both the phase and the amplitude measurements of the first harmonic modulation in the right-ascension distribution. Upper limits on the amplitudes are obtained, which provide the most stringent bounds at present, being below 2% at 99% C.L. for EeV energies. We also compare our results to those of previous experiments as well as with some theoretical expectations.

Large scale anisotripies[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]Auger ExperimentAstronomyAstrophysics::High Energy Astrophysical PhenomenaPhase (waves)FOS: Physical sciencesCosmic rayAstrophysicsanisotropySURFACE DETECTOR01 natural sciencesCosmic RayAugerLarge scale anisotropiesObservatoryLarge scale anisotropie0103 physical sciences010303 astronomy & astrophysicsUltra-high energy cosmic rayCiencias ExactasHigh Energy Astrophysical Phenomena (astro-ph.HE)PhysicsPierre Auger ObservatoryFÍSICA DE PARTÍCULASUltra High Energy Cosmic Rays.010308 nuclear & particles physicsORIGINPhysics[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]Astrophysics::Instrumentation and Methods for AstrophysicsFísicaAstronomy and AstrophysicsPierre Auger ObservatoryUltra-high energy cosmic raysENERGY-SPECTRUMRadiación cósmicaAnisotropíaAmplitudeHarmonicsUltra-high energy cosmic rays; Large scale anisotropies; Pierre Auger ObservatoryExperimental High Energy PhysicsComputingMethodologies_DOCUMENTANDTEXTPROCESSINGARRAYFísica nuclearRight ascensionAstrophysics - High Energy Astrophysical Phenomena
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Search for ultrahigh energy neutrinos in highly inclined events at the Pierre Auger Observatory

2011

Erratum: Phys. Rev. D 85, 029902(E) (2012) [http://dx.doi.org/10.1103/PhysRevD.85.029902]

Physics::Instrumentation and DetectorsSolar neutrinoAstrophysicsUPPER LIMITPHOTON FRACTION01 natural sciences7. Clean energyneutrinoObservatoryHigh Energy Astrophysical Phenomena (astro-ph.HE)PhysicsORIGINPhysics[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]pionAstrophysics::Instrumentation and Methods for AstrophysicsPierre Auger ObservatoryCOSMIC-RAYScosmic ray detectorsand other elementary particle detectorsCosmic neutrino backgroundNEUTRINOSFísica nuclearNeutrinoAstrophysics - High Energy Astrophysical PhenomenaFLUXFERMI-LATNuclear and High Energy Physics[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]TELESCOPEAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesCosmic rayEXTENSIVE AIR-SHOWERSSURFACE DETECTORCosmic RayPionmuon0103 physical sciencesNeutrino010306 general physicsCosmic raysPierre Auger ObservatoryMuon010308 nuclear & particles physicsFísicaand other elementary particlesUltra-high energy cosmic raysPERFORMANCECosmic rayneutrino flavor; air showers; surface detector; observatory; atmosphere; Auger; cosmic radiation; energy spectrum13. Climate actionHigh Energy Physics::Experiment
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The effect of the geomagnetic field on cosmic ray energy estimates and large scale anisotropy searches on data from the Pierre Auger Observatory

2011

We present a comprehensive study of the influence of the geomagnetic field on the energy estimation of extensive air showers with a zenith angle smaller than $60^\circ$, detected at the Pierre Auger Observatory. The geomagnetic field induces an azimuthal modulation of the estimated energy of cosmic rays up to the ~2% level at large zenith angles. We present a method to account for this modulation of the reconstructed energy. We analyse the effect of the modulation on large scale anisotropy searches in the arrival direction distributions of cosmic rays. At a given energy, the geomagnetic effect is shown to induce a pseudo-dipolar pattern at the percent level in the declination distribution t…

[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Astrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencescosmic ray experimentCosmic rayAstrophysicsultra high energy cosmic raysEXTENSIVE AIR-SHOWERS01 natural sciencesDeclinationultra high energy cosmic ray0103 physical sciencescosmic rays detectors; cosmic ray experiments; ultra high energy cosmic rayscosmic rays detectorAnisotropyInstrumentation and Methods for Astrophysics (astro-ph.IM)010303 astronomy & astrophysicsZenithParticle detectors.Pierre Auger ObservatoryPhysics010308 nuclear & particles physicsPhysicsOBSERVATÓRIOSAstrophysics::Instrumentation and Methods for AstrophysicsFísicaAstronomy and Astrophysics[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]AzimuthMODELEarth's magnetic fieldPhysics::Space PhysicsLarge detector systems for particle and astroparticle physicARRAYFísica nuclearcosmic rays detectorscosmic ray experimentsAstrophysics - Instrumentation and Methods for AstrophysicsEnergy (signal processing)Cherenkov detectorJournal of Cosmology and Astroparticle Physics
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