0000000000617367

AUTHOR

F. Cicciò

showing 5 related works from this author

More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children

2017

Objective. To evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with growth hormone deficiency (GHD).Design. 32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, 16 patients) or TIW (group B, 16 patients) GHT for 12 months.Methods. Auxological parameters, insulin-like growth factor-I (IGF-I), glucose and insulin during OGTT, glycosylated hemoglobin (HbA1c), lipid profile, the oral disposition index (DIo), the homeostasis model assessment estimate of insulin resistance (Homa-IR), and the insulin sensitivity index (ISI).Results. After 12 months, both groups showed a s…

0301 basic medicinemedicine.medical_specialtyArticle SubjectEndocrinology Diabetes and Metabolismmedicine.medical_treatment030209 endocrinology & metabolismgrowth hormone deficiency childrenlcsh:Diseases of the endocrine glands. Clinical endocrinologyGroup BGrowth hormone deficiencySettore MED/13 - Endocrinologia03 medical and health sciences0302 clinical medicineEndocrinologyInsulin resistanceInternal medicinemedicinelcsh:RC648-665medicine.diagnostic_testEndocrine and Autonomic Systemsbusiness.industryInsulinmedicine.diseaseGrowth hormone treatmentRegimen030104 developmental biologyEndocrinologyClinical StudyHemoglobinbusinessLipid profileInternational Journal of Endocrinology
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High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement tr…

2014

PURPOSE: Although the correlation between vitamin D and growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis is documented, as of date, few and conflicting studies have prospectively analyzed vitamin D before and after GH treatment. Our aim was to evaluate as to how the condition of GH deficiency (GHD) or GH treatment influences vitamin D in children. METHODS: Eighty Sicilian GHD children (M/F 58/22; mean age 10.3 years), grouped according to the season of evaluation in group A (June-September; 41 children) and group B (November-February; 39 children), were evaluated at baseline and after 12 months of GH treatment. RESULTS: Twenty-eight children (35 %) were vitamin D insufficient an…

Malemedicine.medical_specialtyAdolescentHormone Replacement TherapyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentComorbidityGrowth hormoneGrowth hormone deficiencySettore MED/13 - EndocrinologiaYoung AdultEndocrinologyHypovitaminosisInternal medicinemedicineVitamin D and neurologyPrevalenceHumansChildDwarfism Pituitaryvitamin D growth hormoneHigh prevalencebusiness.industryHuman Growth HormoneGrowth factorInfantmedicine.diseaseVitamin D DeficiencyEndocrinologyTreatment OutcomeChild PreschoolGh treatmentFemalebusinessGH Deficiency
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Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency.

2016

OBJECTIVE: GH treatment (GHT) can lead to glucose metabolism impairment through decreased insulin sensitivity and impaired pancreatic β-cell function, which are the two key components of the pathogenesis of diabetes. Therefore, in addition to insulin sensitivity, during GHT it is very important to perform a reliable evaluation of insulin secretion. However, conflicting data exist regarding the insulin secretion in children during GHT. C-peptide provides a more reliable estimate of β-cell function than insulin, but few studies evaluated it during GHT. Our aim was to assess the usefulness of C-peptide in the evaluation of insulin secretion in GH deficiency (GHD) children. DESIGN: In 48 GHD ch…

Male0301 basic medicinemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatment030209 endocrinology & metabolismBiologyGlucagonHypopituitarismGrowth hormone deficiencySettore MED/13 - Endocrinologia03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEndocrinologyInsulin resistanceInsulin-Secreting CellsDiabetes mellitusInternal medicineInsulin SecretionmedicineHumansInsulinC-peptide growth hormone deficiencyProspective StudiesInsulin-Like Growth Factor IChildGlucose tolerance testC-Peptidemedicine.diagnostic_testHuman Growth HormoneC-peptideInsulinFastingGlucose Tolerance TestGlucagonmedicine.diseaseHormonesGrowth hormone treatment030104 developmental biologyEndocrinologychemistryArea Under CurveCase-Control StudiesChild PreschoolFemaleInsulin Resistance
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Revaluation of the clinical and metabolic behavior of children with isolated growth hormone deficiency during GH treatment according to newly propose…

2015

Purpose To evaluate the clinical and metabolic behavior of children with isolated growth hormone (GH)-deficiency (GHD), grouped according to the new AIFA criteria for the appropriateness of use and reimbursement of GH treatment in children. Methods The clinical and metabolic data of 310 prepubertal children (220 M, 90 F; mean age 10.8 years) grouped, according to new AIFA note 39, into group A (No 181 with a peak of GH 10 µg/L) were retrospectively analyzed. Group A and B, diagnosed as having GHD, were treated with GH for at least 24 months, while group C was analyzed only at baseline. Results At baseline, group A showed higher waist circumference than B (p=0.031) and C (p=0.041), while no …

Malemedicine.medical_specialtyWaistAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentGroup AGroup BGrowth hormone deficiencySettore MED/13 - Endocrinologiachemistry.chemical_compoundGovernment AgenciesEndocrinologyInternal medicineOutcome Assessment Health CaremedicineHumansChildDwarfism PituitaryGrowth hormone childrenbusiness.industryCholesterolInsulinmedicine.diseaseEndocrinologyItalychemistryChild PreschoolGrowth HormoneConcomitantPractice Guidelines as TopicGh treatmentFemalebusinessFollow-Up Studies
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Clinical and metabolic impact of three-times-weekly versus daily growth hormone (GH) treatment in naïve GH-deficient children

2017

OBJECTIVE: Growth hormone treatment (GHT) is commonly administered daily, although pulsatile GH secretion is unlikely to be achieved. The auxological effect of a three-injections-per-week (TIW) regimen is controversial, while the metabolic effects have been never evaluated in children. The objective was to evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with GH deficiency (GHD). DESIGN: 32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, No 16) or TIW (group B, No 16) GHT for 12 months. METHODS: Auxological parameters, insulin-like growth factor-I (IGF-I), glucos…

growth hormoneSettore MED/13 - Endocrinologia
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