0000000000620813
AUTHOR
C. Belloir
Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation
The effects of in vivo administration of naturally occurring organosulfur compounds (OSCs) from Allium species were studied on the activation of several mutagens. Male SPF Wistar rats were given p.o. one of either diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide (DPS) or dipropyl disulfide (DPDS) during 4 consecutive days and the ability of hepatic S9 and microsomes from treated rats to activate benzo[a]pyrene (BaP), cyclophosphamide (CP), dimethylnitrosamine (DMN), N-nitrosopiperidine (N-PiP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was determined in the Ames test. Administration of DAS, DPS and DPDS resulted in a significant increase of the activation of…
Evidence for interactions between aroma compounds and the CB1 receptor: a way to regulate food intake?
National audience; Obesity is a major cause of morbidity and mortality worldwide, characterised by a chronic imbalance of energy homeostasis. The regulation of dietary intake appears to be an effective way to regulate this imbalance. Furthermore, it is now well established that the endocannabinoid system influences appetite via the cannabinoid receptor type 1 (CB1): CB1 agonists can promote food intake while CB1 antagonists tend to decrease appetite (1). Interestingly, recent studies showed that CB1-like receptors are expressed in the olfactory epithelium of Xenopus laevis tadpoles (2). Elsewhere, it has been demonstrated that aroma perception is implicated in the process of satiety (3). Co…