Author: Muller-esterl W

0000000000621206

AUTHOR

Muller-esterl W

Ontogeny of bradykinin B2 receptors in the rat kidney: Implications for segmental nephron maturation

Ontogeny of bradykinin B 2 receptors in the rat kidney: Implications for segmental nephron maturation. Kinins modulate renal function, yet their role in the developing kidney is largely unknown. To explore the developmental role of the kallikrein-kinin system, we examined the postnatal ontogeny and intrarenal localization of B 2 receptors in the rat. Northern blot analysis and RT-PCR documented the expression of B 2 receptor mRNA in the kidney and extrarenal tissues of fetal, neonatal and adult animals. The abundance of B 2 receptor mRNA is 10- to 30-fold higher in neonatal than adult tissues in the following order: kidney > heart > aorta > lung > brain. Receptor autoradiography revealed a …

research product

Developmental activation and segment-specific co-expression of kininogen and bradykinin (BK) B2-receptors during rat nephrogenesis. • 2143

Developmental activation and segment-specific co-expression of kininogen and bradykinin (BK) B 2 -receptors during rat nephrogenesis. • 2143

research product

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