0000000000621478

AUTHOR

Schino P.

showing 3 related works from this author

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma.

2021

Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics. Methods: About 202 severe asthmatics were studied after 12–120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV1 > 12% or ≤12% changes differentiated RAO+ from RAO− subjects. Blood eosinophil (BE) counts after treatment were considered. Results: Pre-/post-treatment bronchodilator FEV1% and ACT were lower (61% [50–71], 74.4% [62.5–83.7] and 20[18–22]), …

Pulmonary and Respiratory Medicinesevere asthmamedicine.medical_specialtymedicine.drug_classSevere asthmaEosinophilSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyPersistence (computer science)03 medical and health sciences0302 clinical medicineInternal medicineBronchodilatorallergic asthma blood eosinophil bronchodilator reversibility lung function decline severe asthma salbutamolForced Expiratory VolumemedicineSettore MED/10Immunology and AllergyHumans030212 general & internal medicineBlood eosinophilLungGenetics (clinical)Lung functionBronchodilator Agentallergic asthma; blood eosinophil; bronchodilator reversibility; lung function decline; severe asthma; salbutamol; bronchodilator agents; eosinophils; forced expiratory volume; humans; lung; airway obstruction; asthmabusiness.industrylung function declineAirway obstructionmedicine.diseaseAsthmaBronchodilator AgentsAirway ObstructionEosinophilsbronchodilator reversibility030228 respiratory systemsalbutamolSalbutamolBlood eosinophilsbusinessallergic asthmamedicine.drugHumanblood eosinophilThe clinical respiratory journalREFERENCES
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Correction: Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study (BMC Pulmonary Med…

2019

Following publication of the original article [1], the authors flagged that the article had been provided with the names of the authors (not including the STORICO study group) in the wrong order: the 'Given Names' and Family Names' were erroneously swapped around. Please see this table for the correct order of the names: (Table Presented) This error has now been corrected in the original article and the corrected author list is detailed in this article.

COPD Symptoms
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As-needed anti-inflammatory reliever therapy for asthma management: evidence and practical considerations

2021

Asthma is a chronic respiratory disease in which airway inflammation is a key feature, even in the milder expressions of the disease. The conventional pharmacological approach to mild asthma has long relied on reliever therapy with as-needed short-acting beta-agonists (SABAs), while anti-inflammatory maintenance with inhaled corticosteroids (ICSs) has been reserved for patients with more persistent asthma. Poor adherence to maintenance treatment is an important issue in asthma management, and can partly explain suboptimal symptom control. Over-reliance on SABA bronchodilators for rapid symptom relief is common in real life and potentially leads to an increased risk of asthma morbidity and m…

0301 basic medicineBudesonidemedicine.medical_specialtyImmunologySettore SECS-P/03Anti-Inflammatory AgentsSocio-culturaleDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioAsthma managementasthma; pharmacology and pharmacogenomics; pneumology03 medical and health sciences0302 clinical medicineSymptom reliefMaintenance therapymedicineImmunology and AllergyHumansAnti-Asthmatic AgentsPneumologyIntensive care medicineAsthmaAsthma Pharmacology and pharmacogenomics Pneumologybusiness.industryInhalerPharmacology and pharmacogenomicsRespiratory diseasepharmacology and pharmacogenomicmedicine.diseaseAsthmarespiratory tract diseasesBronchodilator Agents030104 developmental biology030228 respiratory systembusinessmedicine.drug
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