Taste receptors signalling

International audience

A screening for genes encoding G protein-coupled receptors expressed in taste papillae

International audience

Taste receptors to L-glutamate

National audience

INTERACTION OF TAS1RS WITH FILAMIN AN ACTIN BINDING PROTEIN

Nonsynonymous SNPs in human tas1r1, tas1r3, mGluR1 and individual taste sensitivity to glutamate

 ; Nonsynonymous SNPs in human tas1r1, tas1r3, mGluR1 and individual taste sensitivity to glutamate. 31. annual meeting - Association for chemoreception sciences (AChemS)

A binary genetic approach to characterize TRPM5 cells in mice

International audience; Transient receptor potential channel subfamily M member 5 (TRPM5) is an important downstream signaling component in a subset of taste receptor cells making it a potential target for taste modulation. Interestingly, TRPM5 has been detected in extra-oral tissues; however, the function of extra-gustatory TRPM5-expressing cells is less well understood. To facilitate visualization and manipulation of TRPM5-expressing cells in mice, we generated a Cre knock-in TRPM5 allele by homologous recombination. We then used the novel TRPM5-IRES-Cre mouse strain to report TRPM5 expression by activating a tau GFP transgene. To confirm faithful coexpression of tau GFP and TRPM5 we gene…

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

International audience; Rats and mice exhibit a spontaneous attraction for lipids. Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids. The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (LCFAs) and is found in lingual papillae in the rat. To explore this hypothesis further, experiments were conducted in rats and in wild-type and CD36-null mice. In mice, RT-PCR experiments with primers specific for candidate lipid-binding proteins revealed that only CD36 expression was restricted to lingual papillae although absent from the palatal papill…

Taste perception and behavior in rodents and flies

Taste, one of the five senses, plays a key role in food ingestion. The recent identification of molecular markers for taste cells (e.g., taste receptors and signaling components) has provided tools to investigate the functional organization of the gustatory system. This new information contributes to our understanding of taste-associated behaviors.

CK36, un sérieu jalon sur la piste du goût du gras

Meshing individual differences in taste sensitivity with genotype: cSNPs in candidate taste receptors for glutamate are necessary but not sufficient to explain specific ageusia

International audience

TASTE RECEPTORS FOR GLUTAMATE IN HUMAN FUNGIFORM PAPILLAE

International audience

FAT/CD36: ROLE IN ORAL FATTY ACIDS DETECTION

Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae.

International audience; Monosodium glutamate as well as metabotropic and ionotropic glutamate receptor agonists have been reported to be perceived as umami by humans. In spite of the fact that Tas1R1-Tas1R3 has been shown to mediate most of the glutamate taste sensation in mice other candidate receptors have been put forward for which a clear role in detection is still lacking. This work was aimed at investigating the molecular determinants underlying umami taste detection in humans. First, we show evidence supporting expression of Tas1R1 and Tas1R3 but not mGluRs in the fungiform papillae of several individuals. Next, we report a number of naturally occurring l-glutamate taste receptor var…

Piecing together the taste signaling puzzle

International audience; The identification of the genes coding for bitter, umami, sweet and sour taste receptors has provided us with unique tools to investigate the gustatory system. As a consequence, tremendous progress towards our understanding of the functional organization of the peripheral taste system has been achieved over the past decade. In particular, key components of the taste receptors signaling cascades have been identified as well as populations of chemosensory cells in the olfactory, respiratory and digestive systems expressing taste receptors. Besides sharing receptors and signaling molecules (gustducin, phospholipase-C b2…) with taste bud cells, these cells display a simi…

CD36, un sérieux jalon sur la piste du goût du gras

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Non synonymous nucleotide polymorphisms in human taste receptors and individual taste sensitivity to glutamate

National audience

Les récepteurs du goût

National audience

Relation phénotype-génotype dans le cas de la sensibilité gustative au glutamate

National audience

ROLE OF THE CHORDA TYMPANI AND GLOSSOPHARYNGEAL NERVES IN ORAL LINOLEIC ACID DETECTION IN MICE

Phenotype genotype relationship in human taste

International audience