0000000000623124

AUTHOR

Ugo Ala

showing 2 related works from this author

Author response: Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

2020

Immature neuronVariation (linguistics)Phylogenetic treeEvolutionary biologyLayer (object-oriented design)Biology
researchProduct

Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

2020

The adult mammalian brain is mainly composed of mature neurons. A limited amount of stem cell-driven neurogenesis persists in postnatal life and is reduced in large-brained species. Another source of immature neurons in adult brains is cortical layer II. These cortical immature neurons (cINs) retain developmentally undifferentiated states in adulthood, though they are generated before birth. Here, the occurrence, distribution and cellular features of cINs were systematically studied in 12 diverse mammalian species spanning from small-lissencephalic to large-gyrencephalic brains. In spite of well-preserved morphological and molecular features, the distribution of cINs was highly heterogeneou…

0301 basic medicineimmature neurons10017 Institute of AnatomyQH301-705.5Science610 Medicine & healthGeneral Biochemistry Genetics and Molecular Biologyneuroscience03 medical and health sciences0302 clinical medicinedoublecortin1300 General Biochemistry Genetics and Molecular Biology2400 General Immunology and MicrobiologyneocortexmedicinemammalsBiology (General)brain size; doublecortin; immature neurons; mammals; neocortex; neuroscienceImmature neuronNeocortexGeneral Immunology and MicrobiologybiologyPhylogenetic treeGeneral NeuroscienceQNeurogenesisR2800 General NeuroscienceGeneral MedicineMammalian brainDoublecortin030104 developmental biologymedicine.anatomical_structurebrain sizeCerebral cortexBrain sizebiology.proteinMedicine570 Life sciences; biologyNeuroscience030217 neurology & neurosurgeryeLife
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