0000000000624110
AUTHOR
Egija Zole
showing 4 related works from this author
Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population
2014
Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geographic location, and/or specific historic background. The aims of this study were to identify a specific hg which correlates with aging in a Latvian populating and to evaluate the possible association of TL variability with specific mitochondrial hgs. The results show no significant correlation between TL, mitochondrial DNA hgs and longevity. A slight increase in frequency was obse…
Analysis of the bacterial communities in ancient human bones and burial soil samples: Tracing the impact of environmental bacteria
2019
Abstract In our attempts to reveal the hidden fragments of the history of the natural world, ancient DNA (aDNA) is the precious missing key that allows us to discover hidden truths about ourselves and the world around us. Not only does aDNA encrypt genetic data from a particular individual, it also carries information about the microbial communities that were present in the individual. However, the process of such data mining has many intrinsic challenges. One of the main challenges in aDNA research is the contamination of archaeological material with environmental bacteria from the surrounding soil and postmortem microbial sources. The goal of this study was to identify the microbial commu…
Mitochondrial DNA copy number and telomere length in peripheral blood mononuclear cells in comparison with whole blood in three different age groups
2019
There are more and more studies on telomere length (TL) and mitochondrial DNA (mtDNA), and it has been proven that these factors play a significant role in the aging of the immune system thereby it is important to understand how it varies in different cell types for more accurate conclusions. The aim of this study was to look into dynamics of mtDNA amount in conjunction with TL in peripheral blood mononuclear cells (PBMC) during aging in comparison with whole blood (WB) cells. Overall, 53 samples were divided into three age groups: 20-39 year age group, 40-59 year age group and 60-79 year age group. MtDNA amount was determined by qPCR TaqMan, and TL was measured by Southern blotting of term…
Interrelation of mitochondrial DNA and telomere length alterations in ageing human population
2018
Līdz šim nav veikti pētījumi Latvijas populācijā, kas aprakstītu telomēru garuma (TG) un mitohondriālā DNS (mtDNS) izmaiņas, un to saistību novecošanas procesā. Tas ir zināms, ka telomēri un mitohondriji ir savā starpā saistīti un virza izmaiņas šūnu līmenī novecojot. Šie signāl-ceļi var būt atkarīgi no nelielām izmaiņām kodola DNS vai mtDNS, novedot pie paātrinātas novecošanās vai slimībām. Savā darbā esmu apstiprinājusi, ka šie divi šūnu komponenti ir svarīgi un ir saistīti ar novecošanos. Kā arī parādīju, ka TG un mtDNS izmaiņas ir savādākas cilvēkiem, kuri nodzīvo pāri 90 gadiem. Kā arī, ka labdabīgas vai nelielas mtDNS sekvenču izmaiņas neietekmē TG, mtDNS daudzumu asins šūnās vai ilgd…