Sicilian transitional waters: Current status and future development

To appraise the current knowledge of Sicilian transitional waters (TWs), a review was undertaken of the information available on these ecosystems. In detail, a synthesis of the current status is reported, highlighting for each area the ecological features and status, historical data, conservation regime, environmental emergencies and anthropic pressures to which they are subject. The Sicilian TWs reviewed include coastal ponds and lakes, mires and areas with active and nonactive saltworks. Almost all of these ecosystems are affected by several protection regimes because of their high naturalistic value, although current knowledge is limited and fragmented. A few areas have received more att…

Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BSC) or Bsc Alone: Subanalysis of the Phase III Mission Trial

ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…

Seagrasses along the Sicilian coasts

All seagrass species known from the Mediterranean basin have been recorded along the Sicilian coast, where studies have been carried out at a very local scale and information is fragmented or confined to the grey literature. The objective of this article is to summarise and evaluate current knowledge on seagrass species on the Sicilian coasts, providing an overview of species distribution, genetic diversity, biology and ecology, based on the literature and unpublished data. Most literature studies have been carried out on Posidonia oceanica meadows because of their wide distribution, complexity and ecological importance. In this study, the analyses carried out on P. oceanica structural and …

A PATIENT WITH FRONTOTEMPORAL DEMENTIA (FTD) AND MOTOR NEURON DISEASE (MND) CARRYING THE INTRON10+29 SUBSTITUTION IN MAPT

Neuropathological and clinical phenotype of an Italian Alzheimer family with M239V mutation of Presenilin 2 gene

DISFUNZIONE MULTIORGANO (MOF) IN CORSO DI ENCEFALOPATIA NEONATALE. INDAGINE EPIDEMIOLOGICA SU UN CAMPIONE DI NEONATI OSSERVATI NEL PERIODO GENNAIO 2009 - MAGGIO 2016

encefalopatia, disfunzione multirogano