Author: Jan Bressler

0000000000624725

AUTHOR

Jan Bressler

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Blood DNA Methylation and Incident Coronary Heart Disease

2021

IMPORTANCE American Indian communities experience a high burden of coronary heart disease (CHD). Strategies are needed to identify individuals at risk and implement preventive interventions. OBJECTIVE To investigate the association of blood DNA methylation (DNAm) with incident CHD using a large number of methylation sites (cytosine-phosphate-guanine [CpG]) in a single model. DESIGN, SETTING, AND PARTICIPANTS This prospective study, including a discovery cohort (the Strong Heart Study [SHS]) and 4 additional cohorts (the Women's Health Initiative [WHI], the Framingham Heart Study [FHS], the Atherosclerosis Risk in Communities Study ([ARIC]-Black, and ARIC-White), evaluated 12 American Indian…

Malemedicine.medical_specialtyTime FactorsCoronary DiseaseFramingham Heart StudyRisk FactorsInternal medicinemedicineHumansProspective StudiesProspective cohort studyAgedOriginal InvestigationAsianProportional hazards modelbusiness.industryIncidenceWomen's Health InitiativeHazard ratiodNaMDNA MethylationMiddle AgedMicroarray AnalysisUnited StatesCohortDNA methylationFemaleCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesJAMA Cardiology

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