0000000000626031

AUTHOR

Virdis A

showing 4 related works from this author

Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project

2021

Abstract Background Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database. Methods Clinica…

NephrologyAdultMalemedicine.medical_specialtySettore MED/09 - Medicina Interna030232 urology & nephrologyAllopurinolRenal functionHyperuricemia030204 cardiovascular system & hematologyKidneyurologic and male genital diseasesGastroenterology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineSerum uric acidRisk FactorsInternal medicineDiabetes mellitusmedicineeGFRHumansAlbuminuriaHyperuricemiaRenal Insufficiency ChronicAgedbusiness.industryAlbuminuria; Cardiovascular risk; Serum uric acid; eGFRnutritional and metabolic diseaseseGFR.Middle Agedmedicine.diseaseCardiovascular riskUric AcidchemistryNephrologyAlbuminuriaUric acidAlbuminuria; Cardiovascular risk; eGFR; Serum uric acidOriginal ArticleFemalemedicine.symptombusinessmedicine.drugKidney diseaseGlomerular Filtration Rate
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Serum uric acid and fatal myocardial infarction: Detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

2019

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AdultMalemedicine.medical_specialtyAdolescentPhysiologycut-off value030204 cardiovascular system & hematology03 medical and health scienceschemistry.chemical_compoundYoung Adult0302 clinical medicineuric acidInternal medicineInternal MedicinemedicineORIGINAL PAPERS: EpidemiologyHumanssex030212 general & internal medicineHyperuricemiaMyocardial infarctionRisk factorAgedAged 80 and overuric acid cardiovascular arterial hypertensioncut-off value mortality myocardial infarctionsex uric acidProportional hazards modelbusiness.industrycut-off value mortality myocardial infarction sex uric acidHazard ratioMiddle Agedmedicine.diseasePrognosismortalityConfidence intervalUric acid myocardial infarction epidemiologymyocardial infarctionchemistryItalyHypertensionComputingMethodologies_DOCUMENTANDTEXTPROCESSINGcut-off value; mortality; myocardial infarction; sex; uric acidUric acidFemaleCardiology and Cardiovascular MedicinebusinessCohort study
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The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk

2021

Abstract Introduction Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis. Aim We assessed the prognostic role of SUA in patients with and without MS. Methods We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure. Results A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previousl…

Malemedicine.medical_specialtySettore MED/09 - Medicina InternaCardiovascular mortalityPrognosiSudden cardiac deathchemistry.chemical_compoundSerum uric acidRisk FactorsInternal medicineCause of DeathmedicineHumansSerum uric acid.Myocardial infarctionCardiovascular mortality; Metabolic syndrome; Prognosis; Serum uric acidStrokeRetrospective StudiesOriginal Paperbusiness.industryProportional hazards modelHazard ratioGeneral MedicineMiddle Agedmedicine.diseasePrognosisMetabolic syndromeUric AcidSurvival RatechemistryItalyCardiovascular DiseasesHeart failureCardiologyUric acidFemaleMetabolic syndromeCardiology and Cardiovascular MedicinebusinessBiomarkersFollow-Up Studies
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A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke

2004

CONTEXT: Myocardial infarction (MI) and ischemic stroke are thought to be caused by matrix digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques. Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E(2) synthesis. Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear. OBJECTIVE: To investigate the relationship between the -765G-->C polymorphism of the COX-2 gene and clinically evident plaque rupture. DESIGN, SETTING, AND PARTICIPANTS: Prospective, matched case-control study conducted between March 2002 and October 2003 among 864 pa…

MalePathologySettore MED/09 - Medicina InternaArteriosclerosisCarotid StenosiMyocardial InfarctionInfarctionProstacyclinGastroenterologyCohort StudiesCerebrovascular AccidentrteriosclerosiRisk FactorsGenotypeMedicineCarotid StenosisProspective StudiesMyocardial infarctionMembrane ProteinStrokebiologyGeneral MedicineMiddle AgedIsoenzymesStrokePhenotypeMatrix Metalloproteinase 9Matrix Metalloproteinase 2FemaleHumanmedicine.drugmedicine.medical_specialtyGenotypeArteriosclerosiInternal medicineDiabetes mellitusHumansPolymorphism Geneticbusiness.industryC-reactive proteinProstaglandin-Endoperoxide SynthaseMembrane Proteinsmedicine.diseaseEpoprostenolIsoenzymeProspective StudieAtheromaCyclooxygenase 2Prostaglandin-Endoperoxide Synthasesbiology.proteinCohort Studiebusiness
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