DEVELOPMENTAL ASPECTS OF DRUG METABOLISM

Publisher Summary This chapter discusses the developmental aspects of drug metabolism and those of other biological phenomena that are twofold. Development is described by examining various species of different levels of biological evolution or by studying the ontogenetic evolvement of the features in question in one animal species or groups of related species. A review on diene-organochlorine insecticides epitomizes the fact that insects, birds, and fish possess the enzymatic mechanisms for epoxidation of these insecticides to only a slightly less degree than do mammals. Thus, the ability to oxidize foreign compounds does not seem to be restricted to animals of higher organization, and con…