0000000000626649
AUTHOR
A. R. Boccaccini
In vitro bioactivity study of composite scaffold prepared via thermally induced phase separation
Among porous materials suitable for Bone Tissue Engineering (BTE) scaffolds, bioactive ceramics (hydroxyapatite, HA) and bioactive glasses (BG) have been used for their excellent biocompatibility, bioactivity and efficient osteointegration (1). However, their major limitations are brittleness, low mechanical stability and low dissolution rate (2). Recent evidences suggest that composite scaffold based on biodegradable polymers (e.g. Poly-lacticacid (PLLA)) simultaneously loaded with HA and BG hold promising potential as efficient osteoconductive implants (3, 4). In this work we investigated the possibility to produce composite PLLA-HA-BG scaffolds via Thermally Induced Phase Separation (TIP…
Tubular composite scaffolds produced via Diffusion Induced Phase Separation (DIPS) as a shaping strategy for anterior cruciate ligaments reconstruction
Injuries of tendons and ligaments are common, especially among the young population. Anterior cruciate ligament (ACL) injuries do not heal due to its limited vascularization and hence, surgical intervention is usually required. The ideal scaffold for ligament tissue engineering (TE) should be biocompatible and possess mechanical and functional characteristics comparable to the native ACL. The Diffusion Induced Phase Separation (DIPS) technique allows the preparation of homogenous porous tubular scaffold with micro-pores using a rather simple procedure. Composites based on biodegradable polymers and bioglass have attracted much attention in tissue reconstruction and repair because of their b…
BIOGLASS® integration in Poly-L-Lactic-Acid scaffolds produced via Thermally Induced Phase Separation (TIPS).
In this work, a method of integration of BG particles in polymeric scaffold was developed with a trial and error procedure. The main purpose was to obtain highly porous and mechanically stable bioactive devices.