0000000000626988

AUTHOR

A. Bavuso Volpe

showing 1 related works from this author

A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting.

2015

Two derivatives of hyaluronic acid (HA) have been synthesized by atom transfer radical polymerization (ATRP), starting from an ethylenediamino HA derivative (HA-EDA) and by using diethylaminoethyl methacrylate (DEAEMA) as a monomer for polymerization. Both samples, indicated as HA-EDA-pDEAEMA a and b, are able to condense siRNA, as determined by gel retardation assay and resulting complexes show a size and a zeta potential value dependent on polymerization number, as determined by dynamic light scattering measurements. In vitro studies performed on HCT 116 cell line, that over express CD44 receptor, demonstrate a receptor mediated uptake of complexes, regardless of their surface charge. New…

Materials Chemistry2506 Metals and AlloyssiRNA deliveryGenetic VectorsBioengineeringATRPATRP; CD44; hyaluronic acid; siRNA delivery; tumor targeting; Antigens CD44; Cell Line Tumor; Drug Delivery Systems; Humans; Methacrylates; Neoplasm Proteins; Genetic Vectors; Hyaluronic Acid; Neoplasms; RNA Small Interfering; Biotechnology; Bioengineering; Biomaterials; Polymers and Plastics; Materials Chemistry2506 Metals and AlloysMethacrylateNeoplasm ProteinDrug Delivery SystemsCell Line TumorNeoplasmsHumansCD44Hyaluronic AcidRNA Small InterferingPolymers and Plastictumor targetingBiomaterialAntigens CD44Neoplasm ProteinsHyaluronan ReceptorsNeoplasmMethacrylatesGenetic VectorDrug Delivery SystemHumanBiotechnologyMacromolecular bioscience
researchProduct