0000000000626989

AUTHOR

F. Bongiovì

showing 3 related works from this author

A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting.

2015

Two derivatives of hyaluronic acid (HA) have been synthesized by atom transfer radical polymerization (ATRP), starting from an ethylenediamino HA derivative (HA-EDA) and by using diethylaminoethyl methacrylate (DEAEMA) as a monomer for polymerization. Both samples, indicated as HA-EDA-pDEAEMA a and b, are able to condense siRNA, as determined by gel retardation assay and resulting complexes show a size and a zeta potential value dependent on polymerization number, as determined by dynamic light scattering measurements. In vitro studies performed on HCT 116 cell line, that over express CD44 receptor, demonstrate a receptor mediated uptake of complexes, regardless of their surface charge. New…

Materials Chemistry2506 Metals and AlloyssiRNA deliveryGenetic VectorsBioengineeringATRPATRP; CD44; hyaluronic acid; siRNA delivery; tumor targeting; Antigens CD44; Cell Line Tumor; Drug Delivery Systems; Humans; Methacrylates; Neoplasm Proteins; Genetic Vectors; Hyaluronic Acid; Neoplasms; RNA Small Interfering; Biotechnology; Bioengineering; Biomaterials; Polymers and Plastics; Materials Chemistry2506 Metals and AlloysMethacrylateNeoplasm ProteinDrug Delivery SystemsCell Line TumorNeoplasmsHumansCD44Hyaluronic AcidRNA Small InterferingPolymers and Plastictumor targetingBiomaterialAntigens CD44Neoplasm ProteinsHyaluronan ReceptorsNeoplasmMethacrylatesGenetic VectorDrug Delivery SystemHumanBiotechnologyMacromolecular bioscience
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HYALURONIC ACID/-CYCLODEXTRINS HYDROGEL FOR CORNEAL RELEASE OF EPITHELIAL CELLS AND DEXAMETHASONE

2015

hyaluronic acid beta cyclodextrinSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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PRODUCTION VIA MICROFLUIDICS OF FIBRILLAR AND NANOMETRIC BIOMATERIALS FOR REGENERATIVE MEDICINE AND DRUG DELIVERY POURPOSES

2019

Microfluidic technique offers mild operating conditions suitable for fabrication of fibers and cell encapsulation and can be applied for controlled production of nanometric biomaterials1 . Ionotropic polysaccharides are routinely employed for microfluidics. To be processed, nonionotropic polysaccharides, such as Hyaluronic Acid (HA), should be chemically crosslinked during fabrication2 . In order to avoid chemical crosslinking, we designed an ionic strenght sensible HA derivative suitable for microfluidics2 . Here we describe the use of such HA derivative for fabrication of fibrillar and nanometric biomaterials for regenerative medicine and drug delivery applications. For muscle tissue rege…

MICROFLUIDICS BIOMATERIALS REGENERATIVE MEDICINE DRUG DELIVERY
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