0000000000627393
AUTHOR
Alain Bousquet-mélou
Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma Virus
International audience; A series of 43 antiviral corrole-based molecules have been tested on myxoma virus (Lausanne-like T1MYXV strain). An autofluorescent MYXV, with an ANCHOR cassette, has been used for the studies. A(2)B-fluorocorroles display various toxicities, from 40 being very toxic (CC50 = 1.7 mu M) to nontoxic 38 (CC50 > 50 mu M), whereas A(3)-fluorocorroles, with one to three fluorine atoms, are not toxic (with the exception of corroles 9, 10, and 22). In vitro, these compounds show a good selectivity index when used alone. Corrole 35 seems to be the most promising compound, which displays a high selectivity index with the lowest IC50. Interestingly, this "Hit" corrole is easy to…
Impact d'une antibiothérapie précoce sur l'efficacité de la marbofloxacine lors d'infection pulmonaire expérimentale à Pasteurella multocida
Nous avons émis l'hypothèse que le traitement précoce d'animaux infectés pourrait se révéler bénéfique en termes de santé animale.
Effects of early versus late treatments by marbofloxacin in a mouse-model of Pasteurella multocida pulmonary infection
In veterinary medicine, the administration of antimicrobial drugs to animals before the onset of the syndromes of bacterial infection may be regarded as an irrational and useless antibiotic consumption.