0000000000628074

AUTHOR

Anna Janina Engstler

showing 3 related works from this author

P-14ROLE OF TUMOR NECROSIS FACTOR ALPHA IN THE REGULATION OF ALCOHOL DEHYDROGENASE ACTIVITY IN THE LIVER: STUDIES IN OB/OB MICE

2015

Studies suggest that the activity of hepatic ADH is regulated at least in parts by gender, age and body weight. It further has been shown that hormones but also insulin signaling pathways may be involved in ADH activity. However, molecular mechanisms have not yet been fully understood. The aim …

medicine.medical_specialtyAlcohol dehydrogenase activityInsulin receptorEndocrinologyInternal medicinemedicinebiology.proteinTumor necrosis factor alphaGeneral MedicineBiologyBody weighthormones hormone substitutes and hormone antagonistsHormoneAlcohol and Alcoholism
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Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors

2014

Apoptosis signaling is involved in both physiological tissue homeostasis and acute and chronic diseases. The role of regulatory apoptosis signaling molecules and their organ-specific functions are less defined. Therefore, we investigated the loss of the anti-apoptotic cellular FLICE-inhibitory protein (cFLIP) and the mechanisms of the resulting lethal organ failure in vivo using inducible knockout mice. These were generated by crossing floxed cFLIP mice to a tamoxifen inducible Rosa26-creERT2 mouse strain. Death following global loss of cFLIP resulted from liver failure, accumulation of M1-polarized macrophages and accompanying hepatic cell death and inflammation. Apoptosis was also promine…

Programmed cell deathCASP8 and FADD-Like Apoptosis Regulating ProteinMice TransgenicInflammationBiologyMiceImmune systemmedicineAnimalsMolecular BiologyTissue homeostasisOriginal PaperInnate immune systemMacrophagesMembrane ProteinsCell BiologyLiver Failure AcuteImmunity InnateCell biologyToll-Like Receptor 4TransplantationApoptosisToll-Like Receptor 9Stimulator of interferon genesHepatocytesmedicine.symptomCell Death & Differentiation
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Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease

2015

Objective Increased fasting blood ethanol levels, suggested to stem from an increased endogenous ethanol synthesis in the GI tract, are discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to further delineate the mechanisms involved in the elevated blood ethanol levels found in patients with NAFLD. Design In 20 nutritionally and metabolically screened children displaying early signs of NAFLD and 29 controls (aged 5–8 years), ethanol plasma levels were assessed. Ethanol levels along the GI tract, in vena cava and portal vein, intestinal and faecal microbiota, and activity of alcohol dehydrogenase (ADH) and cytochrome P450…

Male0301 basic medicinemedicine.medical_specialtyStatistics as TopicEndogenyBody Mass IndexMice03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInsulin resistanceNon-alcoholic Fatty Liver DiseaseInternal medicinemedicineAnimalsHumansNutritional Physiological PhenomenaEthanol metabolismChildAlcohol dehydrogenaseEthanolEthanolbiologyFatty liverAlcohol DehydrogenaseGastroenterologyCytochrome P-450 CYP2E1CYP2E1medicine.disease030104 developmental biologyEndocrinologyLiverchemistryChild Preschoolbiology.proteinFemale030211 gastroenterology & hepatologyInsulin ResistanceAntibodyGut
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