0000000000630459

AUTHOR

Alex Sánchez-pla

showing 1 related works from this author

Non-targeted metabolomic biomarkers and metabotypes of type 2 diabetes: A cross-sectional study of PREDIMED trial participants

2019

Aim. - To characterize the urinary metabolomic fingerprint and multi-metabolite signature associated with type 2 diabetes (T2D), and to classify the population into metabotypes related to T2D. Methods. - A metabolomics analysis using the 1 H-NMR-based, non-targeted metabolomic approach was conducted to determine the urinary metabolomic fingerprint of T2D compared with non-T2D participants in the PREDIMED trial. The discriminant metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to establish and to assess the multi-metabolite signature of T2D prevalence, respectively. Metabotypes associated with T2D were identified using the k-means algorithm. Results. - A …

Male0301 basic medicineOncologyNon targetedendocrine system diseasesCross-sectional studyEndocrinology Diabetes and MetabolismType 2 diabetesDiet MediterraneanLogistic regressionDiabetis no-insulinodependentEndocrinologyRisk FactorsNon-insulin-dependent diabetesDietoteràpiaeducation.field_of_studyFactors de risc en les malaltiesBiochemical markersGeneral MedicineMiddle AgedMetabolismeMetabolòmicaCardiovascular DiseasesMarcadors bioquímicsMetabolomeFemalemedicine.medical_specialtyRisk factors in diseasesPopulationUrinalysis03 medical and health sciencesMedicina preventivaMetabolomicsInternal medicineInternal MedicinemedicineHumansMetabolomicseducationAgedPreventive medicineReceiver operating characteristicbusiness.industryDiet therapynutritional and metabolic diseasesmedicine.diseasePredimedMetabolismCross-Sectional Studies030104 developmental biologyDiabetes Mellitus Type 2businesshuman activitiesBiomarkersDiabetic AngiopathiesDiabetes & Metabolism
researchProduct