0000000000637221

AUTHOR

Christopher W. Wheat

showing 3 related works from this author

Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource

2021

Abstract Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome datasets from natural populations of this species have been published over the last 20 years. A major challenge is the integration of these disparate datasets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution and population structure of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequenc…

0106 biological sciences0303 health scienceseducation.field_of_studyPopulationPopulation geneticsGenomicsGenome browserComputational biologyInformation repositoryBiology010603 evolutionary biology01 natural sciencesGenome03 medical and health sciencesComputingMethodologies_PATTERNRECOGNITIONHologenome theory of evolutionEvolutionary dynamicseducation030304 developmental biology
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The era of reference genomes in conservation genomics

2022

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics.

QH301 Biology580 Plants (Botany)Genetics -- ResearchEvolutionsbiologibiodiversity conservation; conservation genetics; ERGA; European Reference Genome AtlasConservation genetics; Biodiversity conservation; European Reference Genome Atlas; ERGAAnimal genome mappingudc:630*1GenomeGEERGA[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE][SDE.BE.BIOD]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.biodERGA ; Biodiversity [MeSH] ; Genomics [MeSH] ; Ecology Evolution Behavior and Systematics ; conservation genetics ; Genome [MeSH] ; biodiversity conservation ; European Reference Genome Atlas3rd-DASGenomicsBiodiversityreferenčni genomi[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM][SDE.BE.BEC]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.becChemistry10121 Department of Systematic and Evolutionary BotanygenomikaGE Environmental Sciences:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]biodiverzitetaSettore BIO/18 - GENETICAeducationQH426 GeneticsQH301European Reference Genome AtlasVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470[SDE.BE.EVO]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.evoGeneticsconservation genetics ; biodiversity conservation ; European Reference Genome Atlas ; ERGAgenomi10211 Zurich-Basel Plant Science CenterGenomesGenetikBiologyQH426Ecology Evolution Behavior and SystematicsEvolutionary BiologyBiodiversity conservation; Conservation genetics; European Reference Genome AtlasAmbientaleEcologíaGenética1105 Ecology Evolution Behavior and Systematicsconservation geneticsWildlife conservation570 Life sciences; biologyHuman medicinebiodiversity conservationAnimal genetics[SDE.BE]Environmental Sciences/Biodiversity and EcologyGenètica
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Drosophila Evolution over Space and Time (DEST) : A New Population Genomics Resource

2021

Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome datasets from natural populations of this species have been published over the last years. A major challenge is the integration of disparate datasets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequencies using either a heuristic (PoolSNP) or a…

0106 biological sciencesdrosophilia melanogasterdemographyQH301 BiologyadaptationAcademicSubjects/SCI0118001 natural sciencesGene Frequencymedia_common0303 health sciencesEuropean researchbioinformatiikkaGenomics3rd-DASgenomiikkaNew populationResourcesDrosophila melanogaster; SNPs; adaptation; demography; evolution; population genomicsDrosophila melanogasterpopulaatiogenetiikkaChristian ministryCorrigendumSNPsResource (biology)population genomicsEvolutionevoluutioLibrary scienceQH426 GeneticsBiology010603 evolutionary biology03 medical and health sciencesQH301evolutionGeneticsmedia_common.cataloged_instanceAnimalsEuropean unionAdaptationMolecular BiologyQH426Ecology Evolution Behavior and Systematics030304 developmental biologyDemographyAcademicSubjects/SCI01130banaanikärpänenNISGenetics PopulationComputingMethodologies_PATTERNRECOGNITIONResearch councilMCPperimäMetagenomicsPopulation genomics
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