0000000000637298
AUTHOR
Erich Schaumlöffel
Pharmakologisch-aktive polymere, 21. Orientierende Untersuchungen zur körperverteilung und Ausscheidung von poly[2-(methylsulfinyl)ethylacrylat]en bei der Ratte
Poly[2-(methylsulfinyl)ethyl acrylate] (1) was synthesized as well as derivatives 14C-labelled in side groups (6) or 14C-labelled in the main chain (11). Polymer 11 with the 14C-labelled main chain was fractionated by precipitation. The η-M-relation determined by measurements of unlabelled polymers in the ultracentrifuge for comparison was used to establish the viscosimetrically determined molecular weights of the labelled fractions. After intravenous application of aqueous solutions of the polymer in rats the excretion rate up to 72 h after treatment was ascertained to ca. 50%; the concentration in the blood serum was found to be strikingly high. A tendency to reinforced storage in organs …
Pharmakologisch-aktive polymere, 18. Körperverteilung und ausscheidungsverhalten von monomerem und polymerem sulfadiazinacrylamid
Sulfadiazinacrylamid was absorbed after oral and intraperitoneal application in rats to a high extent; the absorption from the intraperitoneum was retarded. Glucose treatment delayed the absorption after both application forms. At comparatively high renal and enteral excretion rates the biological half life time of the monomer was estimated to 8 h. A tumouraffinity was not found but there were indications for a preferred storage in the RES. Poly[sulfadiazinacrylamide] was absorbed after intraperitoneal injection to a clear extent, where at the beginning of the treatment under simultaneous glucose load the absorption was delayed. 24 h after injection higher concentrations in metabolic organs…