0000000000638052

AUTHOR

Jose F. Sotillo

showing 2 related works from this author

Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers

2011

AdultMalePlatelet aggregationPlatelet AggregationFlowerslaw.inventionYoung AdultRandomized controlled trialFibrinolytic AgentslawHealthy volunteersMedicineHumansAnalysis of VarianceCrataegusCross-Over StudiesbiologyTraditional medicineAspirinbusiness.industryPlant ExtractsHematologybiology.organism_classificationCrossover studyCrataegus laevigataPlant LeavesThromboxane B2SpainFemaleAnalysis of variancebusinessPlatelet Aggregation Inhibitors
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Hawthorn extract inhibits human isolated neutrophil functions.

2008

Hawthorn extract is a popular herbal medicine given as adjunctive treatment for chronic heart failure. In contrast to the cardiac properties of hawthorn extract, its anti-inflammatory effect has been scarcely investigated. This study examines the effects of a dry extract of leaves and flowers of Crataegus laevigata on various functional outputs of human neutrophils in vitro. Incubation of human neutrophils obtained from peripheral blood of healthy donors with C. laevigata extract (0.75-250 microg/ml) inhibited N-formyl-Met-Leu-Phe (FMLP)-induced superoxide anion generation, elastase release and chemotactic migration with potency values of 43.6, 21.9, and 31.6 microg/ml, respectively. By con…

AdultLeukotriene B4NeutrophilsFlowersPharmacologyIn Vitro TechniquesLeukotriene B4Calcium in biologychemistry.chemical_compoundPhagocytosisExtracellularMedicineHumansRespiratory BurstPharmacologyCrataegusbiologyChemotactic FactorsSuperoxidebusiness.industryPlant ExtractsElastasebiology.organism_classificationRespiratory burstCrataegus laevigataN-Formylmethionine Leucyl-PhenylalaninePlant LeavesChemotaxis LeukocytechemistryBiochemistryAdjunctive treatmentCytokinesCalciumbusinessLeukocyte ElastasePharmacological research
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