0000000000639461

AUTHOR

Michele Cannone

showing 3 related works from this author

Oxaliplatin, irinotecan, and fluorouracil/folinic acid in advanced gastric cancer: a multicenter phase II trial of the Southern Italy Cooperative Onc…

2009

Purpose: This phase II trial assessed the tolerability and efficacy of a triplet of oxaliplatin, irinotecan, and fluorouracil/folinic acid in advanced gastric cancer. Methods: Patients with unresectable or metastatic gastric cancer, unexposed to palliative chemotherapy, received oxaliplatin 85 mg/m 2 iv and irinotecan 150 mg/m2 iv on day 1, 6S-folinic acid 250 mg/m2 iv and fluorouracil 750 mg/m2 iv on day 2, every 2 weeks. Response rate (RR) was assessed after a minimum of four cycles, and treatment continued up to 12 cycles. Results: Sixty-three patients were treated, with a median of eight (range 1-12) cycles/patient. Two complete and 19 partial responses were registered (RR 33% [95% CI, …

OncologyMaleCancer ResearchOrganoplatinum CompoundsAntimetabolitesSettore MED/06 - Oncologia Medicamedicine.medical_treatmentAntidotesLeucovorinKaplan-Meier EstimateToxicologyPhytogenicAntineoplastic Combined Chemotherapy Protocols80 and overMedicinePharmacology (medical)Stomach cancerTomographyAged 80 and overMiddle AgedAntineoplasticMagnetic Resonance ImagingX-Ray ComputedOxaliplatinOncologyFluorouracilFemaleFluorouracilmedicine.drugAdultmedicine.medical_specialtyAntimetabolites AntineoplasticAntineoplastic AgentsNeutropeniaAdenocarcinomaIrinotecanFolinic acidStomach NeoplasmsTomography X-Ray Computed; Male; Aged 80 and over; Antimetabolites Antineoplastic; Middle Aged; Kaplan-Meier Estimate; Camptothecin; Survival Analysis; Female; Fluorouracil; Adenocarcinoma; Leucovorin; Humans; Organoplatinum Compounds; Antineoplastic Agents; Stomach Neoplasms; Magnetic Resonance Imaging; Antidotes; Blood Cell Count; Antineoplastic Combined Chemotherapy Protocols; Antineoplastic Agents Phytogenic; Aged; AdultInternal medicineHumansAgedPharmacologyChemotherapybusiness.industryGastric cancerFluorouracilIrinotecan OxaliplatinTriplet regimenmedicine.diseaseAntineoplastic Agents PhytogenicSurvival Analysisdigestive system diseasesOxaliplatinBlood Cell CountIrinotecanCamptothecinbusinessTomography X-Ray ComputedFebrile neutropeniaCancer chemotherapy and pharmacology
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Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: resul…

2023

Abstract Aims Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting. Methods and results In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P …

Cardiogenic shock GEIST IABP In-hospital complications Intra-aortic balloon counter-pulsation Stress cardiomyopathy Takotsubo syndrome
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Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syn…

2019

IMPORTANCE Takotsubo syndrome (TTS) is an acute, reversible heart failure syndrome featured by significant rates of in-hospital complications. There is a lack of data for risk stratification during hospitalization. OBJECTIVE To derive a simple clinical score for risk prediction of in-hospital complications among patients with TTS. DESIGN, SETTING, AND PARTICIPANTS In this prognostic study, 1007 consecutive patients were enrolled in the German and Italian Stress Cardiomyopathy (GEIST) registry from July 1, 2007, through December 31, 2017, and identified as the derivation cohort; 946 patients were enrolled in the Spanish Registry for Takotsubo Cardiomyopathy (RETAKO) as the external score val…

Malemedicine.medical_specialtyPopulationCardiomyopathy030204 cardiovascular system & hematologyRisk AssessmentVentricular Function Leftlaw.invention03 medical and health sciences0302 clinical medicinelawRisk FactorsTakotsubo CardiomyopathyInternal medicineGermanymedicineHumans030212 general & internal medicineRegistrieseducationAgedHeart Failureeducation.field_of_studyInpatientsFramingham Risk ScoreEjection fractionbusiness.industryCardiogenic shockIncidenceTakotsubo SyndromeStroke Volumemedicine.diseasePrognosisIntensive care unitSurvival RateItalyROC CurveEchocardiographyHeart failureFemaleCardiology and Cardiovascular MedicineComplicationbusinessJAMA cardiology
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