0000000000640109

AUTHOR

Robb U. De Iongh

0000-0001-7013-1610

showing 1 related works from this author

Ocular Phenotype of Relaxin Gene Knockout (Rln-/-) Mice

2020

Purpose: To test if relaxin deficiency affects ocular structure and function we investigated expression of relaxin (Rln) and RXFP receptors (Rxfp1, Rxfp2), and compared ocular phenotypes in relaxin gene knockout (Rln-/- ) and wild type (Rln+/+ ) mice. Materials and Methods: Rln, Rxfp1 and Rxfp2 mRNA expression was detected in ocular tissues of Rln+/+ mice using RT-PCR. The eyes of 11 Rln-/- and 5 Rln+/+ male mice were investigated. Corneal and retinal thickness was assessed using optical coherence tomography. Intraocular pressure was measured using a rebound tonometer. Retinal, choroidal and sclera morphology and thickness were evaluated histologically. Eyes were collected and fixed for imm…

MalePathologymedicine.medical_specialtygenetic structuresAquaporinsReal-Time Polymerase Chain ReactionRetinaReceptors G-Protein-CoupledCorneaGene Knockout TechniquesMiceTonometry Ocular03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compound0302 clinical medicineCorneamedicineAnimalsRNA MessengerIntraocular PressureGene knockoutMice KnockoutRelaxinExtracellular Matrix ProteinsRetinaChoroidChemistryRelaxinRetinalFluid transporteye diseasesSensory SystemsScleraMice Inbred C57BLOphthalmologyPhenotypemedicine.anatomical_structureGene Expression Regulation030221 ophthalmology & optometryImmunohistochemistryFemalesense organsScleraTomography Optical Coherence030217 neurology & neurosurgeryCurrent Eye Research
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