0000000000640396

AUTHOR

Homa Taheri

showing 2 related works from this author

HLA-DRB1*1301 AND *1302 protect against chronic hepatitis B

1997

Abstract Background/Aims: The outcome of acute hepatitis B infection may be influenced by host factors like the major histocompatibility complex (MHC). We have investigated MHC class I and class II antigens in patients with chronic hepatitis B compared to a healthy control population. To confirm the findings of this first study we performed a second study in a group of subjects who had spontaneously recovered from acute hepatitis B infection. Methods: Frequencies of MHC class I and class II antigens were analyzed in patients with chronic hepatitis B virus infection and in control subjects. MHC class I typing was done by standard microlymphocytotoxicity assays. DRB1 and DQA1 genotypes were d…

AdultHepatitis B virusRemission SpontaneousPopulationEnzyme-Linked Immunosorbent AssayMajor histocompatibility complexmedicine.disease_causePolymerase Chain ReactionHLA-DQ alpha-ChainsVirusHLA-DQ AntigensMHC class ImedicineHumansSerologic TestsProspective StudiesHepatitis B AntibodieseducationHLA-DRB1AllelesHepatitis B viruseducation.field_of_studyMHC class IIHepatitis B Surface AntigensHepatologybiologyHLA-DR AntigensHepatitis BVirologyChronic infectionImmunoglobulin GChronic DiseaseDNA ViralImmunologybiology.proteinHLA-DRB1 ChainsJournal of Hepatology
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MHC class II genes influence the susceptibility to chronic active hepatitis C

1997

Chronic hepatitis C develops in more than 70% of hepatitis C virus infected subjects. Viral factors influence the disease course, but little is known about the importance of host factors.Frequencies of major histocompatibility complex (MHC) class I and class II antigens were analyzed in two groups of patients with chronic hepatitis C virus infection and in control subjects. MHC class I typing was done by standard microlymphocytotoxicity assays. DRB1 and DQA1 genotyping was done by PCR based typing methods.DRB1*0301 was found in 26 of 75 patients with chronic hepatitis C virus infection (34.7%) and in 12 of 101 control subjects (11.9%) (relative risk 3.9; p0.001). Homozygosity for this allel…

GenotypeHepatitis C virusGenes MHC Class IIBiologymedicine.disease_causePolymerase Chain ReactionHLA-DQ alpha-ChainsVirusMHC Class II GeneReference ValuesHLA-DQ AntigensMHC class ImedicineHumansGenetic Predisposition to DiseaseAllelesAntilymphocyte SerumHepatitis ChronicHepatitisMHC class IIHepatologyHistocompatibility Antigens Class IHomozygoteHistocompatibility Antigens Class IIHLA-DR AntigensHepatitis Cmedicine.diseaseHepatitis CVirologyHistocompatibilityImmunologyDisease Progressionbiology.proteinDisease SusceptibilityHLA-DRB1 ChainsJournal of Hepatology
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