showing 2 related works from this author
Halogen‐Imparted Reactivity in Lithium Carbenoid Mediated Homologations of Imine Surrogates: Direct Assembly of bis‐Trifluoromethyl‐β‐Diketiminates a…
2020
The selective formal insertion (homologation) of a carbon unit bridging the two trifluoroacetamidoyl chlorides (TFAICs) units is reported. The tactic is levered on a highly chemoselective homologation-metalation-acyl nucleophilic substitution sequence which precisely enables to assemble novel trifluoromethylated β-diketiminates within a single synthetic operation. Unlike previous homologations conducted with LiCH2Cl furnishing aziridines, herein we exploit the unique capability of iodomethyllithium to act contemporaneously as a C1 source (homologating effect) and metalating agent. The mechanistic rationale grounded on experimental evidences supports the hypothesized proposal and, the struct…
CCDC 2007131: Experimental Crystal Structure Determination
2020
Related Article: Laura Ielo, Laura Castoldi, Saad Touqeer, Jessica Lombino, Alexander Roller, Cristina Prandi, Wolfgang Holzer, Vittorio Pace|2020|Angew.Chem.,Int.Ed.|59|20852|doi:10.1002/anie.202007954