0000000000645962

AUTHOR

Holger Schön

showing 3 related works from this author

Hemoglobin, C-reactive protein and ferritin in patients with oral carcinoma and their clinical significance – A prospective clinical study

2017

For oral squamous cell carcinoma (OSCC), biomarkers are much in need to predict prognosis and to overcome possible resistance mechanisms to adjuvant therapies. The aim of this study was to evaluate serum level of hemoglobin, C-reactive protein (CRP) and ferritin as possible liquid biopsy to predict survival, metastasis and tumor relapse of OSCC.A prospective clinical study was conducted. Overall, serum levels of hemoglobin, CRP and ferritin in 82 OSCC patients and 63 controls were preoperatively investigated.Patients with an anemia showed a significant lower survival than patients with no anemia preoperative. Patients with T3/T4 cancer had significant lower hemoglobin values (p = 0.002). CR…

Malemedicine.medical_specialtyAnemiaGastroenterologyHemoglobins03 medical and health sciences0302 clinical medicineInternal medicineBiomarkers TumormedicineCarcinomaHumansClinical significanceProspective StudiesLiquid biopsybiologybusiness.industryC-reactive protein030206 dentistryMiddle AgedPrognosismedicine.diseaseSurvival AnalysisHemoglobin CFerritinstomatognathic diseasesC-Reactive ProteinOtorhinolaryngologyCase-Control Studies030220 oncology & carcinogenesisFerritinsCarcinoma Squamous Cellbiology.proteinFemaleMouth NeoplasmsSurgeryHemoglobinOral SurgerybusinessJournal of Cranio-Maxillofacial Surgery
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Proinflammatory cytokines as serum biomarker in oral carcinoma-A prospective multi-biomarker approach.

2017

BACKGROUND Inflammation and cell-mediated immunity have a key role in different stages of carcinogenesis. The aim of this prospective study was to assess serum levels of proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), soluble interleukin-2 receptor (sIL-2R), tumor necrosis factor alpha (TNF-α), and MHC class I polypeptide-related sequence B (MICB) in patients with oral premalignant lesion (OPL), oral squamous cell carcinoma (OSCC), and healthy controls in a multi-biomarker approach as a potential diagnostic and prognostic tool for OSCC. MATERIAL AND METHODS A total of 205 patients (81 with OSCC, 75 with OPL, and 49 healthy controls) were included in this prospective st…

0301 basic medicineAdultMaleCancer Researchmedicine.medical_specialtymedicine.medical_treatmentInflammationGastroenterologyPathology and Forensic MedicineProinflammatory cytokine03 medical and health sciencesYoung Adult0302 clinical medicineInternal medicineCarcinomaBiomarkers TumorMedicineHumansProspective StudiesProspective cohort studySurvival rateAgedAged 80 and overbusiness.industryMiddle Agedmedicine.diseasePrognosisstomatognathic diseases030104 developmental biologyCytokineOtorhinolaryngology030220 oncology & carcinogenesisCase-Control StudiesLymphatic MetastasisCarcinoma Squamous CellPeriodonticsBiomarker (medicine)CytokinesTumor necrosis factor alphaFemaleMouth NeoplasmsOral Surgerymedicine.symptombusinessJournal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
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The matrix metalloproteinase and insulin-like growth factor system in oral cancer : a prospective clinical study

2017

Aim The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters. Results Serum levels of MMP-3 were significantly higher in OSCC patients compared to healthy subjects (p=0.004). Mean IGF-1 and IGFBP-3 levels in OSCC patients were sign…

stomatognathic diseasesMMP610 Medical sciencesserum biomarker610 MedizinOSCCoral premalignant lesionprognosisoral cancerIGFOriginal Research
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