Differentiation induced by 3-aminobenzamide in human osteosarcoma MG-63 cells is mediated by the inhibition of the Wnt/β-catenin pathway

Genomic Analysis by Chromatin Immunoprecipitation Assay (CHIP)

A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein.

Much evidence now indicates that human leucocyte antigen (HLA) class I and class II transgenic (Tg) mice can be of value in analysing HLA-restricted presentation of T-cell epitopes relevant to experimental models of autoimmune diseases. One area where this has been applied is the characterization of myelin epitopes presented by HLA class II molecules in experimental model of multiple sclerosis (experimental allergic encephalomyelitis (EAE)). As a first step towards humanized disease models in HLA Tg mice, we have analysed immune response of lymph node cells of HLA-DR1 Tg mice immunized with the human myelin basic protein (MBP) peptides 13–33, 87–106 and 139–154 bound by HLA-DR1. We report h…

Poly(ADP-ribose) polymerase (PARP): The advantages of using PARP inhibitors to modulate its activity in pathological conditions and to kill cancer cells

PACLITAXEL INDUCES APOPTOSIS IN HUMAN RETINOBLASTOMA Y79 CELLS

In vivo activation of NKT cells exerts different effects in experimental systemic Shwartzmann reaction.

PROLONGED TREATMENT OF HUMAN OSTEOSARCOMA MG63 CELLS WITH 3AB INDUCES THE PRODUCTION OF TUMOR INITIATING CELLS.

TREATMENT OF HUMAN OSTEOSARCOMA CELLS WITH 3AB INDUCES THE APPEARANCE OF CD133+ CELL POPULATION CONTAINING A POTENTIALLY STEM-LIKE PHENOTYPE

mtDNA analysis of the human remains buried in the sarcophagus of Federico II

Abstract The sarcophagus containing the remains of Federico II, located in the Cathedral of Palermo (Sicily, Italy), was opened on 1998 to perform a multidisciplinary survey [1]. Next to the remains of Federico II and in close contact with them were laying two other skeletons belonging, according to historical records, to Pietro II di Aragona and to an anonymous person (“The Third Individual”), probably a woman. The bones appeared severely deteriorated. Chemical analysis performed on bone samples excluded that the bodies underwent some kind of embalming process. The analysis of mtDNA from bone samples taken from the three skeletons was successful in only one of the two labs involved. The HV…