Author: George R. Jackson

0000000000648816

AUTHOR

George R. Jackson

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

AbstractAbout two-thirds of the vital genes in the Drosophila genome are involved in eye development, making the fly eye an excellent genetic system to study cellular function and development, neurodevelopment/degeneration, and complex diseases such as cancer and diabetes. We developed a novel computational method, implemented as Flynotyper software (http://flynotyper.sourceforge.net), to quantitatively assess the morphological defects in the Drosophila eye resulting from genetic alterations affecting basic cellular and developmental processes. Flynotyper utilizes a series of image processing operations to automatically detect the fly eye and the individual ommatidium, and calculates a phen…

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Autophagy

Klionsky, Daniel J. et al.

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PEPhysical Sciences and Engineering
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