0000000000652435
AUTHOR
R Tomasino
Havep53 gene mutations and protein expression a different biological significance in colorectal cancer?
p53 alterations are considered the most common genetic events in many types of neoplasms, including colorectal carcinoma (CRC). These alterations include mutations of the gene and/or overexpression of the protein. The aim of our study was to assess whether in 160 patients undergoing resective surgery for primary operable CRC there was an association between p53 mutations and protein over-expression and between these and other biological variables, such as cell DNA content (DNA-ploidy) and S-phase fraction (SPF), and the traditional clinicopathological variables. p53 mutations, identified by PCR-SSCP-sequencing analysis, were found in 68/160 patients (43%) and positive staining for p53 prote…
Boschiero/del Barrio de la Rosa/Piva/Prandoni (2008), Scrivere tra due culture. Letteratura di migrazione nell’Europa contemporanea
Recensioe a: Manuel Boschiero et al. [a cura di], 2008, Scrivere tra due culture. Letteratura di migrazione nell’Europa contemporanea, Morlacchi Ed., Perugua. In LC, n. 2, 2009, 179 – 188. http://www.dilce.unipa.it/rivista