0000000000652869
AUTHOR
Javier María García López
showing 20 related works from this author
Effect of cytomegalovirus (CMV) serostatus on the incidence and virological features of active CMV infection in allogeneic stem cell transplant recip…
2011
Surveillance for adenovirus DNAemia early after transplantation in adult recipients of unrelated-donor allogeneic stem cell transplants in the absenc…
2011
Surveillance for adenovirus DNAemia early after transplantation in adult recipients of unrelated-donor allogeneic stem cell transplants in the absence of clinically suspected infection
Reconstitution of CMV pp65 and IE-1-specific IFN-γ CD8+ and CD4+ T-cell responses affording protection from CMV DNAemia following allogeneic hematopo…
2011
Threshold levels of CMV-specific T-cell populations presumably affording protection from active CMV infection in allo-SCT recipients have been proposed, but lack extensive validation. We quantified CMV pp65 and immediate-early 1-specific IFN-γ CD8(+) and CD4(+) T cell responses at days +30, +60 and +90 after transplantation in 133 patients, and established cutoff cell levels protecting from CMV DNAemia within the first 120 days after transplantation. No patients showing IFN-γ CD8(+) or IFN-γ CD4(+) T-cell counts1.0 and1.2 cells/μL, respectively, developed a subsequent episode of CMV DNAemia. Initial or recurrent episodes of CMV DNAemia occurred in the face of IFN-γ T-cell levels below defin…
Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemother…
2011
Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y Tratamiento de las Hemopatias Malignas (PETHEMA) and Hemato-Oncologie voor Volwassenen Nederland (HOVON) groups between 1996 and 2005. Results FLT3-internal tandem duplication and FLT3-D835 mutation status was available for 306 (41%) and 213 (29%) patients, respectively. Sixty-eight (22%) and 20 (9%) pa…
An evaluation of the role of NKG2C+natural killer cells in protection from cytomegalovirus DNAemia early following allogeneic stem cell transplantati…
2013
The role of natural killer (NK) cells in affording protection against human cytomegalovirus (CMV) in allogeneic stem cell transplant recipients is largely unknown. The current study was aimed at determining whether NKG2C+ NK cells confer protection from CMV DNAemia early following transplantation in patients lacking mono and polyfunctional CMV pp65 and IE-1-specific CD4+ and CD8+ T-cell responses, as measured by flow cytometry for intracellular cytokine staining. Fourteen out of the 36 patients included in this study developed CMV DNAemia between days +30 and +60 after transplant. Three patients did so after day +60. Peripheral blood levels of CD56(bright) CD16(-/low) and CD56(dim) CD16+ NK…
Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia an…
2009
Rising levels of cytomegalovirus (CMV) DNAemia and/or pp65 antigenemia have been observed during pre-emptive ganciclovir therapy in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). We assessed the incidence of this event in our series, and investigated whether its occurrence was associated with an impairment in the CMV-specific T-cell response. A total of 36 allo-SCT recipients experienced one or more episodes of active CMV infection (n=68) that were pre-emptively treated with val(ganciclovir). Rising levels of antigenemia and DNAemia, and an isolated increase in antigenemia, were observed in 39.7 and 2.9% of all episodes, respectively. Receipt of corticost…
Cytomegalovirus Infection Management in Allogeneic Stem Cell Transplant Recipients: a National Survey in Spain.
2015
ABSTRACT This study gathered information about current practices of cytomegalovirus (CMV) infection management in allogeneic stem cell transplant recipients at Spanish centers. A wide variety of preemptive antiviral therapy strategies for CMV infection guided by real-time PCR assays was found, yet the incidence of CMV disease was low (<3%).
Enumeration of NKG2C+natural killer cells early following allogeneic stem cell transplant recipients does not allow prediction of the occurrence of c…
2015
The role of Natural killer (NK) cells in the control of cytomegalovirus (CMV) infection in allogeneic stem cell transplant recipients has not been precisely characterized. The current study is aimed at investigating the potential role of NK cells expressing the activating receptor NKG2C in affording protection against the development of CMV DNAemia in patients exhibiting detectable CMV-specific CD8+ T-cell responses early following transplantation. A total of 61 nonconsecutive patients were included in the study. Peripheral levels of CD56brightCD16−/low and CD56dimCD16+ NKG2C+ NK cells and CMV pp65/IE-1-specific IFN-γ-producing CD8+ T-cells were enumerated by flow cytometry at days +30 and …
An Assessment of the Effect of Human Herpesvirus-6 Replication on Active Cytomegalovirus Infection after Allogeneic Stem Cell Transplantation
2010
Human herpesvirus-6 (HHV-6) may enhance cytomegalovirus (CMV) replication in allogeneic stem cell transplant (allo-SCT) recipients either through direct or indirect mechanisms. Definitive evidence supporting this hypothesis are lacking. We investigated the effect of HHV-6 replication on active CMV infection in 68 allo-SCT recipients. Analysis of plasma HHV-6 and CMV DNAemia was performed by real-time PCR. Enumeration of pp65 and IE-1 CMV-specific IFNgamma CD8(+) and CD4(+)T cells was performed by intracellular cytokine staining. HHV-6 DNAemia occurred in 39.8% of patients, and was significantly associated with subsequent CMV DNAemia in univariate (P=.01), but not in multivariate analysis (P…
Functional profile of cytomegalovirus (CMV)-specific CD8+ T cells and kinetics of NKG2C+ NK Cells associated with the resolution of CMV DNAemia in al…
2011
Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IE-1-specific CD8(+) T cells expressing IFN-γ, TNF-α, and CD107a, alone or in combination, and NKG2C(+) NK cells were prospectively enumerated during 13 episodes of CMV DNAemia. The expansion of monofunctional and polyfunctional CD8(+) T cells was associated with CMV DNAemia clearance. The size and functional diversity of the expanding CD8(+) T-cell population was greater in self-resolved episodes than in episodes treated with antivirals. These differences were related to the magnitude of expansion of cognate antigen IFN-γ C…
Functional patterns of cytomegalovirus (CMV) pp65 and immediate early-1-specific CD8+T cells that are associated with protection from and control of …
2015
Background The functional profile of cytomegalovirus (CMV)-specific CD8+ T cells that associate with protection from and control of CMV DNAemia in allogeneic stem cell transplant (allo-SCT) recipients remains incompletely characterized. Methods We enumerated pp65 and immediate early (IE)-1-specific CD8+ T cells expressing interferon-gamma, tumor necrosis factor-alpha, and CD107a, by flow cytometry in 94 patients at days +30 and +60 after allo-SCT. Results Fifty of 94 patients had CMV DNAemia within the first 100 days after transplant. CMV-specific CD8+ T-cell responses (of any functional type) were more likely to be detected in patients who did not display CMV DNAemia than in those who did …
Adiciones y revisiones al Atlas de la flora vascular silvestre de Burgos, V
2012
Adiciones y revisiones al Atlas de flora vascular silvestre de Burgos, X
2017
Se mencionan 61 táxones con citas y/o comentarios referidos a su existencia en la provincia de Burgos. De ellos, 3 suponen una novedad para el catálogo provincial 61 taxa with either quotations or remarks, related to their existence within the province of Burgos, are mentioned. 3 out of these aforementioned ones mean a valuable novelty for the provincial catalogue.
Adiciones y revisiones al Atlas de la flora vascular silvestre de Burgos
2016
Se mencionan 31 táxones con citas y/o comentarios referidos a su existencia en la provincia de Burgos. De ellos 8 suponen una novedad para el catálogo provincial. Additions and revisions for the “Atlas de la flora vascular silvestre de Burgos”, IX. 31 Taxa with either quotations or remarks, related to their existence within the province of Burgos, are mentioned. 8 out of these aforementioned ones mean a novelty value for the provincial catalogue.
Adiciones y revisiones al atlas de la flora vascular silvestre de Burgos, I
2008
Se mencionan 104 taxones con citas y/o comentarios referidos a su existencia en la provincia de Burgos. De ellos, 36 suponen una novedad para el catálogo provincial. 104 taxa with either quotations or remarks, related to their existence within the province of Burgos, are mentioned. 36 out of these aforementioned ones, mean a novelty value for the provincial catalogue.
Adiciones y revisiones al Atlas de la flora vascular silvestre de Burgos, VIII
2015
Se mencionan 44 táxones con citas y comentarios referidos a su existencia en la provincia de Burgos. De ellos 3 suponen una novedad para el catálogo provincial. 44 Taxa with either quotations or remarks, related to their existence within the province of Burgos, are mentioned. 3 out of these aforementioned ones mean a novelty value for the provincial catalogue.
Fitoclimatología de Quercus canariensis Willd. en España. Potencialidades y adecuaciones fitoclimáticas
2005
En el presente trabajo se realizan aportaciones a la caracterización fitoclimática de Quercus canariensis Willd. mediante la utilización conjunta de técnicas de diagnosis, de homologación y de evaluación de idoneidades fitoclimáticas así como de técnicas de cartografía digital y de evaluación de variables regionalizadas. Quercus canariensis se encuentra en las provincias Gaditano-onubo-algarviense (sector Gaditano) y Luso-extremadurense (Sector Mariánico-monchiquense) en los subtipos fitoclimáticos IV2, IV4 y VI(IV)3, en la provincia Catalano-valenciano-provenzal (sector Vallesano- empordanés) en el subtipo IV(VI)2 y en la provincia pirenaica (sector pirenaico occidental) en los subtipos VI…
Sobre las colecciones burgalesas y otras europeas de Enrique Pérez Arbeláez (1896-1972), depositadas en el Herbario Nacional Colombiano, 3
2018
About Spanish and other European plant collections of Enrique Pérez Arbeláez deposited in the Colombian National Herbarium. After a introduction dedicated to gloss the personality of the Colombian botanist, stopping in some biographical notes, a critical relationship is made on the 214 sheets of the Herbarium of Enrique Pérez Arbeláez. Collections in Europe, collected in Spain between 1922 and 1925, deposited in the Colombian National Herbarium (COL).