Author: Dia̅na Džabijeva

0000000000653010

AUTHOR

Dia̅na Džabijeva

Structure and Stability of Racemic and Enantiopure Pimobendan Monohydrates: On the Phenomenon of Unusually High Stability

Study of structures and physicochemical properties of racemic (rac-H) and enantiopure (enant-H) hydrates of the active pharmaceutical ingredient pimobendan revealed that both hydrates have highly similar crystal structures and exhibit unusually high stability. Both structures contain identical two-dimensional layers and very similar conformations. The most significant difference is the stacking of these layers. The high stability of both hydrates appeared as extremely low solubility over a wide temperature range as well as an exceptionally high dehydration temperature and melting point. Study of the dehydration process showed that both hydrates have different activation energies of dehydrat…

research product

CCDC 1453864: Experimental Crystal Structure Determination

Related Article: Toms Rekis, Agris Be̅rziņš, Dia̅na Džabijeva, Ilva Nakurte, Lia̅na Orola, and Andris Actiņš|2017|Cryst.Growth Des.|17|1814|doi:10.1021/acs.cgd.6b01780

research product

CCDC 1453863: Experimental Crystal Structure Determination

Related Article: Toms Rekis, Agris Be̅rziņš, Dia̅na Džabijeva, Ilva Nakurte, Lia̅na Orola, and Andris Actiņš|2017|Cryst.Growth Des.|17|1814|doi:10.1021/acs.cgd.6b01780

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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