0149: Agonistic anti β3-adrenoceptor antibodies do not affect the β1-adrenoceptor-mediated inotropy and the β3 adrenoceptor-mediated vasorelaxation i…

2014

Cardiac activity of autoantibodies (AABs) directed against β1-adrenoceptor (β1-AR) has been proposed to play an important role in the pathogenesis of dilated cardiomyopathy. Our previous work has shown that the immunization of rats with the second extracellular loop (ECII) of β1-AR induced endothelial dysfunction in aorta and mesenteric arteries. However, until now, no study has explored the cardiovascular effects of β3-AABs alone or combined with β1-AABs.AimTo evaluate whether β3-AABs possess β3-AR agonistic effect and whether active immunization producing β3-AABs and/or β1-AABs has deleterious effects on cardiac and vascular reactivity in Lewis rats.MethodsLewis rats were immunized for 3 …